Rangsinth, Panthakarn and Sharika, Rajasekharan and Sillapachaiyaporn, Chanin and Nilkhet, Sunita and Chaikhong, Kamonwan and Verma, Kanika and Prasansuklab, Anchalee and Ng, Szu-Ting and Tan, Chon-Seng and Fung, Shin-Yee and Tencomnao, Tewin and Chuchawankul, Siriporn (2025) Protective effects of tiger milk mushroom extract (xLr®) against UVB irradiation in Caenorhabditis elegans via DAF-16 anti-oxidant regulation. Journal of Traditional and Complementary Medicine, 15 (1). pp. 73-83. ISSN 2225-4110, DOI https://doi.org/10.1016/j.jtcme.2024.11.004.
Full text not available from this repository.Abstract
Background and aim: A critical causative factor of oxidative stress and inflammation leading to several skin complications is ultraviolet-B (UVB) irradiation. Lignosus rhinocerus (LR), or tiger milk mushroom, is native to Southeast Asia. Cold water extract of an LR cultivar, TM02 (R) (xLr (R)) is a promising anti-oxidant and antiinflammatory source. However, the effects of xLr (R) on UVB-induced photoaging have never been elucidated. Experimental procedure: This study investigated the protective effects of xLr (R) and its high, medium, and low molecular weight (HLR, MLR, and LLR, respectively) fractions against UVB irradiation using in vivo Caenorhabditis elegans (C. elegans) model. Results and conclusion: The investigation revealed a significant lifespan extension of xLr (R) and its fractions in UVBirradiated C. elegans, which could be mediated by the regulation of genes associated with anti-oxidant (daf-16 and sod-3) and apoptosis (cep-1, hus-1, ced-13, and egl-1) pathways. xLr (R) significantly reduced the ROS production in C. elegans and increased the DAF-16 nuclear translocation compared to untreated worms. Additionally, the SOD-3 expression was increased in the xLr (R)-treated worms. Hence, it suggests that the different components in xLr (R) work synergistically to protect against UVB irradiation. Our findings may be beneficial for the application of xLr (R) as a treatment against UVB-induced cellular damage and photoaging.
| Item Type: | Article |
|---|---|
| Funders: | Thailand Science Research and Inno-vation Fund, Chulalongkorn University (CU_FRB65_hea (78) _173_37_03) |
| Uncontrolled Keywords: | Ultraviolet-B; Lignosus rhinocerus; Apoptosis; Photoaging; DAF-16 |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Department of Molecular Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 04 Mar 2025 02:46 |
| Last Modified: | 04 Mar 2025 02:46 |
| URI: | http://eprints.um.edu.my/id/eprint/47803 |
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