Abu Yazib, Syatirah and Choo, May May and Khaliddin, Nurliza and Ong, Christine P. Y. and Choo, Yao Mun and Kamar, Azanna Ahmad and Lingam, Gopal G. and Kamalden, Tengku A. (2025) The association of cytokine levels and postnatal factors with retinopathy of prematurity. Indian Journal of Ophthalmology, 73 (SUPPL). S139-S143. ISSN 0301-4738, DOI https://doi.org/10.4103/IJO.IJO_515_24.
Full text not available from this repository.Abstract
Purpose:Prematurity has been known to trigger several cellular pathways, leading to the clinical occurrence of retinopathy of prematurity (ROP). This study compared the levels of a panel of serum cytokines in premature infants with and without ROP.Methods:This is a prospective observational study. Premature infants at 36-38 weeks' gestational age were recruited, their clinical data recorded, and serum samples collected and assayed for 18 cytokines. Based on follow-up examinations, patients were divided into two groups: No ROP and ROP. The ROP group was further divided into two subgroups: non-vision-threatening ROP (non-VTROP), and vision-threatening ROP (VTROP).Results:On univariate analysis, among the clinical parameters, gestation age, birth weight, duration of invasive ventilation, and duration of stay in neonatal intensive care unit (NICU) were found to be significant. The univariate analysis also showed an association between raised levels of VEGF-D and IL-8 in the VTROP group. Multiple logistic regression indicated that gestation age was a significant risk factor across all subgroups. Additionally, VEGF-D levels were found to be significantly associated with VTROP.Conclusion:Higher VEGF-D levels are associated with an increased risk of severe ROP that requires treatment and could potentially be used as a biomarker.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia (H 20001 E000056), Universiti Malaya Postgraduate Research Student Grant (PG195 2014B), Universiti Malaya Research Grant (RG549 15HTM), University of Sydney |
| Uncontrolled Keywords: | Cytokines; retinopathy of prematurity; ROP |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine Faculty of Medicine > Paediatrics Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Mar 2025 04:46 |
| Last Modified: | 14 Mar 2025 01:06 |
| URI: | http://eprints.um.edu.my/id/eprint/47747 |
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