Maghimaa, M. and Sagadevan, Suresh and Suryadevara, Punna Rao and Sudhan, Hari Hara and Burle, Gowri Sankara Rao and Ruokolainen, Janne and Nelson, Vinod Kumar and Kesari, Kavindra Kumar (2025) Cytotoxicity and targeted drug delivery of green synthesized metallic nanoparticles against oral Cancer: A review. Inorganic Chemistry Communications, 173. p. 113806. ISSN 1387-7003, DOI https://doi.org/10.1016/j.inoche.2024.113806.
Full text not available from this repository.Abstract
Recent advancements in nanotechnology have significantly contributed to developing innovative approaches in cancer therapy, particularly for oral cancer. This review focuses on the promising strategy of using greensynthesized metallic nanoparticles, which possess unique physicochemical properties suitable for targeted drug delivery and enhanced cytotoxicity against cancer cells. These Nanoparticles (NPs) are synthesized through environmentally friendly methods that utilize natural extracts or biomolecules as reducing and stabilizing agents. Their biocompatibility and capacity to penetrate biological barriers make them excellent for delivering therapeutic drugs directly to oral cancer cells, reducing systemic toxicity and increasing the efficacy of therapy. Numerous research on the cytotoxic effects of plant-synthesized Metallic Nanoparticles (MNPs) on oral cancer have demonstrated significant anticancer properties, attributable to their minute size and elevated surface-tovolume ratio. Functionalizing these nanoparticles with targeted ligands, such as peptides or antibodies allows for specific detection and binding to receptors that are overexpressed on cancer cell surfaces. This specific method improves cellular uptake of therapeutic medicines, resulting in enhanced apoptosis and suppression of tumor cell proliferation. Additionally, the tunability of the physicochemical properties of these nanoparticles allows for optimization of their therapeutic efficacy and pharmacokinetics. Overall, this review highlights that green-synthesized metallic nanoparticles can be used to develop targeted and successful diagnosis of the oral cancer treatment.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Oral cancer; Metallic Nanoparticles; Plant extract; Bioactive compounds; Drug delivery |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Mar 2025 06:49 |
| Last Modified: | 14 Mar 2025 00:59 |
| URI: | http://eprints.um.edu.my/id/eprint/47738 |
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