Zolkepli, Husna and Chia, Wen Qi and Othman, Rozana and Awang, Khalijah and Hazni, Hazrina and Sulaiman, Syazreen Nadia and Saidin, Saidatul Husni and Singh, Manroshan Singh Jaswan and Miras, Jonathan and Widodo, Riyanto Teguh and Ahmad, Noraini (2025) Harnessing Brucea Javanica: Development and characterization of lipid-based niosomes for diabetes treatment. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 709 (2). p. 136151. ISSN 0927-7757, DOI https://doi.org/10.1016/j.colsurfa.2025.136151.
Full text not available from this repository.Abstract
Nanotechnology has emerged as a transformative force in drug formulation and targeted delivery, particularly for various pharmaceutical agents. This study focuses on the development and characterization of a lipid nanocarrier, specifically niosomes, encapsulating Brucea javanica (BJ) extract, aimed at treating type 2 diabetes. Niosomes were prepared using a modified ethanol injection method, employing different types of Tween nonionic surfactants, alongside glycolipids. Comprehensive characterization of the BJ extract-loaded niosomes was conducted, evaluating particle size, stability, encapsulation efficiency (EE %), morphology, and in vitro drug release. The formulations exhibited favourable physicochemical properties, with particle sizes between 150 nm and 200 nm, a low polydispersity index ranging from 0.073 to 0.189, and optimal encapsulation efficiency, particularly with Tween 20 as a co-surfactant. Transmission electron microscopy (TEM) revealed that the niosomes were uniformly spherical in shape. Stability assessments confirmed the robustness of the nanocarriers, showcasing minimal fluctuations in particle size and low aggregation rates. Additionally, in vitro release studies indicated a sustained release profile, suggesting enhanced bioavailability of the encapsulated BJ extract. These findings underscore the potential of lipid nanocarriers loaded with BJ extract as a novel therapeutic approach for managing type 2 diabetes, warranting further clinical exploration.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya (IIRG004B-19FNW) ; (BKS001-2024) |
| Uncontrolled Keywords: | Alkyl glucoside; Self-Assembly; Niosome; Brucea javanica; Diabetes |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Centre for Foundation Studies in Science > Chemistry Division Faculty of Science > Department of Chemistry Centre for Natural Products Research and Drug Discovery (CENAR) Faculty of Pharmacy > Department of Pharmaceutical Chemistry Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Mar 2025 07:22 |
| Last Modified: | 14 Mar 2025 01:00 |
| URI: | http://eprints.um.edu.my/id/eprint/47719 |
Actions (login required)
 |
View Item |
