Siew, Li Ying and Lee, Zheng-Yii and Yunos, Nor'azim Mohd and Atan, Rafidah and Cove, Matthew Edward and Lumlertgul, Nuttha and Srisawat, Nattachai and Hasan, M. Shahnaz (2024) Outcomes of extracorporeal blood purification with oXiris® membrane in critically ill patients: A systematic review and meta-analysis. Journal of Critical Care, 83. p. 154844. ISSN 0883-9441, DOI https://doi.org/10.1016/j.jcrc.2024.154844.
Full text not available from this repository.Abstract
Purpose: To evaluate the efficacy of the novel oXiris (R) membrane in critically ill adult patients. Methods: We systematically searched MEDLINE, EMBASE, and CENTRAL from inception to 01/06/2023 for relevant randomised controlled trials (RCTs) and non-randomised studies of intervention (NRSI). The primary outcome was overall mortality. Random effect meta-analyses were conducted in RevMan 5.4.1. Study quality was evaluated using Cochrane's risk of bias tool. (PROSPERO: CRD42023389198). Results: Ten studies (2 RCTs and 8 NRSIs) with 481 patients were included. None had low risk of bias. Treatment using oXiris (R) was associated with reduced overall mortality (RR 0.78, 95%CI 0.62-0.98; p = 0.03; 6 NRSI). One RCT reported 28-day mortality, finding no significant difference between groups. Besides, pooled NRSIs results showed significant reductions in SOFA scores, norepinephrine dosage, and several inflammatory biomarkers (C- reactive protein CRP], lactate, and interleukin-6 IL-6]) post oXiris (R) treatment. However, other clinical outcomes (ICU and hospital length of stay, mechanical ventilation duration) were similar between groups. Conclusion: In critically ill patients, the use of oXiris (R) membrane was associated with reduced overall mortality, norepinephrine dosage, CRP, IL-6, lactate levels, along with improved organ function. However, the certainty of evidence was very low, necessitating high-quality RCTs to further evaluate its efficacy in this population.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Critical illness; Cytokines; Endotoxins; Extracorporeal blood purification; Hemadsorption; oXiris (R) |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Anaesthesiology Department Universiti Malaya Medical Centre (UMMC) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Jan 2025 08:29 |
| Last Modified: | 20 Jan 2025 08:29 |
| URI: | http://eprints.um.edu.my/id/eprint/47583 |
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