Junker, Johanna and Lange, Lara M. and Vollstedt, Eva-Juliane and Roopnarain, Karisha and Doquenia, Maria Leila M. and Annuar, Azlina Ahmad and Avenali, Micol and Bardien, Soraya and Bahr, Natascha and Ellis, Melina and Galandra, Caterina and Gasser, Thomas and Heutink, Peter and Illarionova, Anastasia and Kanana, Yuliia and Sarmiento, Ignacio J. Keller and Kumar, Kishore R. and Lim, Shen-Yang and Madoev, Harutyun and Mata, Ignacio F. and Mencacci, Niccolo E. and Nalls, Mike A. and Padmanabhan, Shalini and Shambetova, Cholpon and Solle, J. C. and Tan, Ai-Huey and Trinh, Joanne and Valente, Enza Maria and Singleton, Andrew and Blauwendraat, Cornelis and Lohmann, Katja and Fang, Zih-Hua and Klein, Christine (2024) Team Science Approaches to Unravel Monogenic Parkinson's Disease on a Global Scale. Movement Disorders, 39 (10). pp. 1868-1873. ISSN 0885-3185, DOI https://doi.org/10.1002/mds.29925.
Full text not available from this repository.Abstract
Background: Until recently, about three-quarters of all monogenic Parkinson's disease (PD) studies were performed in European/White ancestry, thereby severely limiting our insights into genotype-phenotype relationships at a global scale. Objective: To identify the multi-ancestry spectrum of monogenic PD. Methods: The first systematic approach to embrace monogenic PD worldwide, The Michael J. Fox Foundation Global Monogenic PD Project, contacted authors of publications reporting individuals carrying pathogenic variants in known PD-causing genes. In contrast, the Global Parkinson's Genetics Program's Monogenic Network took a different approach by targeting PD centers underrepresented or not yet represented in the medical literature. Results: In this article, we describe combining both efforts in a merger project resulting in a global monogenic PD cohort with the buildup of a sustainable infrastructure to identify the multi-ancestry spectrum of monogenic PD and enable studies of factors modifying penetrance and expressivity of monogenic PD. Conclusions: This effort demonstrates the value of future research based on team science approaches to generate comprehensive and globally relevant results. (c) 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
| Item Type: | Article |
|---|---|
| Funders: | ASAP |
| Uncontrolled Keywords: | Parkinson's disease; GP2; MJFF GMPD; monogenic Parkinson's disease; parkinsonism |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 05 Feb 2025 08:11 |
| Last Modified: | 05 Feb 2025 08:11 |
| URI: | http://eprints.um.edu.my/id/eprint/47553 |
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