Mahat, Nooraini and Chiang, Li Wei and Chen, Yong and Razak, Nazrul Hadi Abdul and Abdullah, Mohd Yusof and Sanmugam, Anand and Singaravel, Srihari and Soe, Htoo Htoo Kyaw and Nah, Shireen Anne (2024) A prospective multicentre study evaluating the performance of the modified simple biliary atresia scoring system in predicting biliary atresia. Pediatric Surgery International, 40 (1). p. 244. ISSN 0179-0358, DOI https://doi.org/10.1007/s00383-024-05830-w.
Full text not available from this repository.Abstract
PurposeEarly diagnosis of biliary atresia (BA) is critical for best outcomes, but is challenged by overlapping clinical manifestations with other causes of obstructive jaundice in neonates. We evaluate the performance of the modified Simple BA Scoring System (SBASS) in diagnosing BA. MethodsWe performed a prospective, cross-sectional study on infants with cholestatic jaundice (June 2021-December 2022). Modified SBASS scoring was applied and compared to the eventual diagnosis (as per intraoperative cholangiogram (IOC) and liver histopathology). The score (0-6), consists of gall bladder length < 1.6 cm (+ 1), presence of triangular cord sign (+ 1), conjugated bilirubin:total bilirubin ratio > 0.7(+ 2), gamma-glutamyl transferase (GGT) >= 200 U/L (+ 2). Results73 were included: Fifty-two (71%) had BA. In the non-BA group, 6 (28%) had percutaneous cholangiography (PTC) while 15 (72%) had intraoperative cholangiogram (IOC). At a cut-off of 3, the modified SBASS showed sensitivity of 96.2%, specificity of 61.9% and overall accuracy of 86.3% in diagnosing BA. Area under receiver operating characteristic curve was 0.901. GGT had the highest sensitivity (94.2%), while triangular cord sign showed the highest specificity at 95.2%. ConclusionThe SBASS provides a bedside, non-invasive scoring system for exclusion of BA in infantile cholestatic jaundice and reduces the likelihood of negative surgical explorations.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Biliary atresia; Scoring; Cholestatic jaundice; Predictive value |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Surgery Department Universiti Malaya Medical Centre (UMMC) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 07 Feb 2025 08:46 |
| Last Modified: | 07 Feb 2025 08:46 |
| URI: | http://eprints.um.edu.my/id/eprint/47503 |
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