Zhou, Xiao-Dong and Chen, Qin-Fen and Yang, Wah and Zuluaga, Mauricio and Targher, Giovanni and Byrne, Christopher D. and Valenti, Luca and Luo, Fei and Katsouras, Christos S. and Thaher, Omar and Misra, Anoop and Ataya, Karim and Oviedo, Rodolfo J. and Kong, Alice Pik-Shan and Alswat, Khalid and Lonardo, Amedeo and Wong, Yu Jun and Abu-Abeid, Adam and Al Momani, Hazem and Ali, Arshad and Molina, Gabriel Alejandro and Szepietowski, Olivia and Jumaev, Nozim Adxamovich and Kizilkaya, Mehmet Celal and Viveiros, Octavio and Toro-Huamanchumo, Carlos Jesus and Kok, Kenneth Yuh Yen and Ospanov, Oral and Abbas, Syed Imran and Robertson, Andrew Gerard and Fouad, Yasser and Mantzoros, Christos S. and Zhang, Huijie and Mendez-Sanchez, Nahum and Sookoian, Silvia and Chan, Wah-Kheong and Treeprasertsuk, Sombat and Adams, Leon and Ocama, Ponsiano and Ryan, John D. and Perera, Nilanka and Sharara, Ala I. and Al-Busa, Said A. and Opio, Christopher Kenneth and Garcia, Manuel and Lim-Loo, Michelle Ching and Ruiz-Ucar, Elena and Prasad, Arun and Casajoana, Anna and Abdelbaki, Tamer N. and Zheng, Ming-Hua (2024) Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021. EClinicalMedicine, 76. p. 102848. ISSN 2589-5370, DOI https://doi.org/10.1016/j.eclinm.2024.102848.
Full text not available from this repository.Abstract
Background Obesity represents a major global health challenge with important clinical implications. Despite its recognized importance, the global disease burden attributable to high body mass index (BMI) remains less well understood. Methods We systematically analyzed global deaths and disability-adjusted life years (DALYs) attributable to high BMI using the methodology and analytical approaches of the Global Burden of Disease Study (GBD) 2021. High BMI was defined as a BMI over 25 kg/m2 for individuals aged >= 20 years. The Socio-Demographic Index (SDI) was used as a composite measure to assess the level of socio-economic development across different regions. Subgroup analyses considered age, sex, year, geographical location, and SDI. Findings From 1990 to 2021, the global deaths and DALYs attributable to high BMI increased more than 2.5-fold for females and males. However, the age-standardized death rates remained stable for females and increased by 15.0% for males. Similarly, the age-standardized DALY rates increased by 21.7% for females and 31.2% for males. In 2021, the six leading causes of high BMI-attributable DALYs were diabetes mellitus, ischemic heart disease, hypertensive heart disease, chronic kidney disease, low back pain and stroke. From 1990 to 2021, low-middle SDI countries exhibited the highest annual percentage changes in age-standardized DALY rates, whereas high SDI countries showed the lowest. Interpretation The worldwide health burden attributable to high BMI has grown significantly between 1990 and 2021. The increasing global rates of high BMI and the associated disease burden highlight the urgent need for regular surveillance and monitoring of BMI. Funding National Natural Science Foundation of China and National Key R&D Program of China. Copyright (c) 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
| Item Type: | Article |
|---|---|
| Funders: | National Natural Science Foundation of China (NSFC) (82070588) ; (82370577), National Key R&D Program of China (2023YFA1800801) |
| Uncontrolled Keywords: | Obesity; Body mass index; Global Burden of Disease Study; Metabolic risk |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Feb 2025 00:52 |
| Last Modified: | 14 Feb 2025 00:52 |
| URI: | http://eprints.um.edu.my/id/eprint/47455 |
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