He, Ziyan and Xu, Qing and Chen, Yang and Liu, Shuya and Song, Huiyin and Wang, Hui and Leaw, Chui Pin and Chen, Nansheng (2024) Acquisition and evolution of the neurotoxin domoic acid biosynthesis gene cluster in Pseudo-nitzschia species. Communications Biology, 7 (1). p. 1378. ISSN 2399-3642, DOI https://doi.org/10.1038/s42003-024-07068-7.
Full text not available from this repository.Abstract
Of the hitherto over 60 taxonomically identified species in the genus of Pseudo-nitzschia, 26 have been confirmed to be toxigenic. Nevertheless, the acquisition and evolution of the toxin biosynthesis (dab) genes by this extensive group of Pseudo-nitzschia species remains unclear. Through constructing chromosome-level genomes of three Pseudo-nitzschia species and draft genomes of ten additional Pseudo-nitzschia species, putative genomic integration sites for the dab genes in Pseudo-nitzschia species were explored. A putative breakpoint was observed in syntenic regions in the dab gene cluster-lacking Pseudo-nitzschia species, suggesting potential independent losses of dab genes. The breakpoints between this pair of conserved genes were also identified in some dab genes-possessing Pseudo-nitzschia species, suggesting that the dab gene clusters transposed to other loci after the initial integration. A ``single acquisition, multiple independent losses (SAMIL)'' model is proposed to explain the acquisition and evolution of the dab gene cluster in Pseudo-nitzschia species. A ``single acquisition, multiple independent losses (SAMIL)'' model is proposed to explain the acquisition and evolution of the domoic acid biosynthesis gene cluster in Pseudo-nitzschia species.
| Item Type: | Article |
|---|---|
| Funders: | Strategic Priority Research Program of Chinese Academy of Sciences (XDB42000000) (XDB42000000), Chinese Academy of Sciences, Chinese Academy of Sciences Pioneer Hundred Talents Program, Taishan Scholar Project Special Fund (19-3-2-16-zhc), Qingdao Innovation and Creation Plan (Talent Development Program - 5th Annual Pioneer and Innovator Leadership Award), Natural Sciences and Engineering Research Council of Canada (NSERC) |
| Subjects: | G Geography. Anthropology. Recreation > GE Environmental Sciences Q Science > Q Science (General) |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Institute of Ocean and Earth Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 17 Feb 2025 05:01 |
| Last Modified: | 17 Feb 2025 05:01 |
| URI: | http://eprints.um.edu.my/id/eprint/47406 |
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