Amrani, Lina and Nekounam Ghadirli, Reyhaneh and Abu Bakar, Umarqayum and Guendouzi, Abdelmadjid and Belkhiri, Lotfi and Azman, Adzzie Shazleen and Hassandarvish, Pouya and Elanie Khairat, Jasmine (2024) In Silico evaluation of the anti-influenza potential of Streptomyces bioactive compounds. Journal of Taibah University for Science, 18 (1). p. 2418429. ISSN 1658-3655, DOI https://doi.org/10.1080/16583655.2024.2418429.
Full text not available from this repository.Abstract
Influenza, a highly contagious respiratory viral disease characterized by its short incubation period and severe symptoms, is treatable with antiviral drugs targeting viremia. Among new antiviral agents, Actinobacteria, particularly from the Streptomyces genus, are notable for their ability to produce potent antiviral compounds. This study evaluates the antiviral potential of Streptomyces sp. KSF 103, isolated from Kuala Sat, Jerantut, Pahang, against the Influenza A virus (IAV). Using molecular docking tools such as AutoDock Vina and PyMOL, the interactions of four compounds - hypoxanthine, vitamin D, purine, and aminocaproic acid - were analyzed against IAV proteins. Vitamin D exhibited the highest binding affinity against H3N2's M2 (-9.6 kcal/mol) and HA (-9.2 kcal/mol) proteins. Additionally, RMSD dynamics parameters indicated that the best-scoring complexes are predicted to be satisfactorily stable under physiological settings. These findings suggest that Streptomyces sp. KSF 103 could be a promising source for developing new antiviral treatments against influenza.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya (FYP-2021), Universiti Malaya (UM) in Malaysia |
| Uncontrolled Keywords: | Influenza A virus; antiviral compound; molecular docking; Streptomyces; vitamin D |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Faculty of Science > Institute of Biological Sciences Centre for Natural Products Research and Drug Discovery (CENAR) Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Mar 2025 01:00 |
| Last Modified: | 20 Mar 2025 01:00 |
| URI: | http://eprints.um.edu.my/id/eprint/47237 |
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