Ratnasingam, Jeyakantha and Lim, Quan Hziung and Chan, Siew Pheng (2025) Type 2 diabetes: a contemporary view from the Asian lens. Current Opinion in Endocrinology, Diabetes and Obesity, 32 (1). pp. 20-25. ISSN 1752-296X, DOI https://doi.org/10.1097/MED.0000000000000895.
Full text not available from this repository.Abstract
Purpose of reviewThe aim of this article was to review the up-to-date evidence with regards to the unique features of the Type 2 diabetes (T2D) pathophysiology, complications, response to therapy with the possibility of precision medicine guiding therapeutic decision making in Asia.Recent findingsAsia is the epicenter of diabetes. There have been marked advances with genotyping and phenotyping of the Asian patient with T2D, particularly with young onset diabetes where early beta cell failure and rapid progression of complications are more frequent. As Asians have lower muscle mass and higher adiposity, sarcopenia is increasingly associated with diabetes. Response to lifestyle and pharmacotherapy are generally similar, but unique features exist with different populations. Across Asia, use of guideline directed medical therapy for cardio-renal protection are recommended, but uptake of these newer agents are suboptimal and barriers exist with regards to standardized care.SummaryAlthough many similarities have been observed across Asia, due to the heterogeneity of populations within Asia, further research is required to streamline and pave the way towards precision medicine. There is an urgent need for region wide consensus to minimize barriers to diabetes care and stigma in diabetes terminology across Asia.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Asia; genotype; guideline-directed medical therapy; phenotype; precision medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Mar 2025 01:37 |
| Last Modified: | 20 Mar 2025 01:37 |
| URI: | http://eprints.um.edu.my/id/eprint/47215 |
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