Liew, Yoon Xuan and Kadir, Kathreena and Phan, Chia Wei and Leong, Kok Hoong and Kallarakkal, Thomas George and Tilakaratne, Wanninayake Mudiyanselage (2024) Salivary biomarkers: Effective diagnostic tool for oral leukoplakia and oral squamous cell carcinoma. Oral Diseases, 30 (6). pp. 3591-3599. ISSN 1354-523X, DOI https://doi.org/10.1111/odi.14835.
Full text not available from this repository.Abstract
ObjectiveTo identify potential salivary biomarkers for the diagnosis and monitoring of disease progression in oral squamous cell carcinoma and oral leukoplakia.Materials and MethodsAn advance search from PubMed and Hindawi was performed with keywords; oral leukoplakia/oral squamous cell carcinoma, salivary biomarker and diagnosis/prognosis. An additional search of articles was done through a manual search from the Google Scholar database.ResultsTwenty studies involving salivary biomarkers as diagnostic tools for oral squamous cell carcinoma and/or oral leukoplakia were identified. A narrative review was carried out.ConclusionSingle or multiple salivary biomarkers reported by most studies have shown great potential as diagnostic tools for oral squamous cell carcinoma and oral leukoplakia. However, the validation of sensitivity and specificity should be carried out to ensure the accuracy of the biomarkers. Furthermore, a standardised method for saliva collection should be established to prevent variability in the expression of biomarkers.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya Impact Oriented Interdisciplinary Research Grant (IIRG001C-2020HWB) |
| Uncontrolled Keywords: | disease management; early diagnosis; oral cancer; oral potentially malignant disorder; salivary biomarker |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry Faculty of Pharmacy |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 09 Dec 2024 06:45 |
| Last Modified: | 09 Dec 2024 06:45 |
| URI: | http://eprints.um.edu.my/id/eprint/47139 |
Actions (login required)
 |
View Item |
