Wong, Wei-Yan and Ismail, Siti Marjiana and Phan, Chia-Wei and Tan, Yee-Shin (2024) Size Matters: Influence of Particle Size on Antioxidant, β-Glucan, and Anti-Inflammatory Potential in Pleurotus floridanus (Agaricomycetes). International Journal of Medicinal Mushrooms, 26 (9). ISSN 1521-9437, DOI https://doi.org/10.1615/IntJMedMushrooms.2024054164.
Full text not available from this repository.Abstract
Cellular damage resulting from elevated levels of free radicals can lead to persistent health issues. Pleurotus floridanus, an edible white oyster mushroom, is rich in beta-glucans with potent antioxidant and anti-inflamma-tory properties. In this research, we examined the beta-glucan content, total phenolic content, as well as antioxidant and anti-inflammatory potential of hot water extracts with varying particle sizes (< 75, 75-154, 154-300, and 300-600 mu m) of both whole and sliced fruiting bodies of P. floridanus. The findings revealed that the beta-glucan content increased as the particle size increased, although no significant differences were observed. Conversely, smaller particle sizes (< 75 mu m) of whole and sliced fruiting bodies of P. floridanus exhibited higher phenolic content, 2,2-diphenyl-1-picryl-hy-drazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging activity, and reducing ability compared with larger particle size (> 75 mu m). Of the four samples (AW2, AW3, AS1, and AS2) with the highest antioxidant activity selected for anti-inflammatory assays, all demonstrated the ability to reduce nitric oxide and tumor necrosis factor-alpha levels, but did not enhance interleukin-10 expression in lipopolysaccharide-stimulated RAW264.7 cells. Interestingly, particle size < 75 to 300 mu m did not appear to influence the anti-inflammatory activity, because no significant differences were observed among the particle sizes. Therefore, a particle size < 300 mu m in a P. floridanushot water extract could serve as a valuable source of antioxidant and anti-inflammatory compounds to counteract the harmful effects of free radicals.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya (Project Code IIRG005A-19HWB) |
| Uncontrolled Keywords: | Pleurotus floridanus; particle size; beta-glucan; antioxidant; anti-inflammatory; medicinal mushrooms |
| Subjects: | Q Science > QH Natural history R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Science > Institute of Biological Sciences Faculty of Pharmacy |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Nov 2024 05:06 |
| Last Modified: | 28 Nov 2024 05:06 |
| URI: | http://eprints.um.edu.my/id/eprint/47124 |
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