Sababathy, M. and Ramanathan, G. and Ganesan, S. and Sababathy, S. and Yasmin, A. R. and Ramasamy, R. and Foo, J. B. and Looi, Q. H. and Nur-Fazila, S. H. (2024) Multipotent mesenchymal stromal/stem cell-based therapies for acute respiratory distress syndrome: current progress, challenges, and future frontiers. Brazilian Journal of Medical and Biological Research, 57. e13219. ISSN 0100-879X, DOI https://doi.org/10.1590/1414-431X2024e13219.
Full text not available from this repository.Abstract
Acute respiratory distress syndrome (ARDS) is a critical, life-threatening condition marked by severe inflammation and impaired lung function. Mesenchymal stromal/stem cells (MSCs) present a promising therapeutic avenue due to their immunomodulatory, anti-inflammatory, and regenerative capabilities. This review comprehensively evaluates MSC-based strategies for ARDS treatment, including direct administration, tissue engineering, extracellular vesicles (EVs), nanoparticles, natural products, artificial intelligence (AI), gene modification, and MSC preconditioning. Direct MSC administration has demonstrated therapeutic potential but necessitates optimization to overcome challenges related to effective cell delivery, homing, and integration into damaged lung tissue. Tissue engineering methods, such as 3D-printed scaffolds and MSC sheets, enhance MSC survival and functionality within lung tissue. EVs and MSC-derived nanoparticles offer scalable and safer alternatives to cell-based therapies. Likewise, natural products and bioactive compounds derived from plants can augment MSC function and resilience, offering complementary strategies to enhance therapeutic outcomes. In addition, AI technologies could aid in optimizing MSC delivery and dosing, and gene editing tools like CRISPR/Cas9 allow precise modification of MSCs to enhance their therapeutic properties and target specific ARDS mechanisms. Preconditioning MSCs with hypoxia, growth factors, or pharmacological agents further enhances their therapeutic potential. While MSC therapies hold significant promise for ARDS, extensive research and clinical trials are essential to determine optimal protocols and ensure long-term safety and effectiveness.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia (FRGS/1/2020/SKK06/UPM/02/16), Malaysia's King Scholarship (Biasiswa Yang Di-Pertuan Agong) |
| Uncontrolled Keywords: | Multipotent mesenchymal stromal/stem cells; Acute respiratory distress syndrome; Treatment strategy; Gene modification; Preconditioning; Tissue engineering |
| Subjects: | Q Science > QA Mathematics > QA75 Electronic computers. Computer science R Medicine > R Medicine (General) |
| Divisions: | Faculty of Computer Science & Information Technology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Nov 2024 01:00 |
| Last Modified: | 28 Nov 2024 01:00 |
| URI: | http://eprints.um.edu.my/id/eprint/47110 |
Actions (login required)
 |
View Item |
