Hamzah, A. M. Che and Yeo, C. C. and Puah, S. M. and Chua, K. H. and Rahman, N. and Ismail, S. and Abdullah, F. H. and Othman, N. and Chew, C. H. (2024) Distribution of virulence genes in clinical isolates of hospital-associated and community-associated methicillin-susceptible Staphylococcus aureus from Terengganu, Malaysia. Tropical Biomedicine, 41 (2). pp. 149-156. ISSN 0127-5720, DOI https://doi.org/10.47665/tb.41.2.003.
Full text not available from this repository.Abstract
Staphylococcus aureus is a common bacterial pathogen known to cause various kinds of infections due to its repertoire of virulence factors. This study aimed to investigate the distribution of 19 types of virulence genes among clinical isolates of methicillin-susceptible S. aureus (MSSA) using the polymerase chain reaction. A total of 109 MSSA isolates, i.e., 63 hospital-associated (HA) and 46 community-associated (CA) were collected from Hospital Sultanah Nur Zahirah, the main tertiary hospital in Terengganu, Malaysia, from July 2016 to June 2017. The most frequent virulence genes detected were hla (78.9%, n =86) and hld (78.0%, n =85) encoding hemolysins, lukED (56.9%, n =62) encoding leukotoxin ED, followed by seb (26.6%, n =29) and sea (24.8%, n =27) encoding enterotoxins. Among 34 (31.2%) isolates carrying six or more virulence genes, only five were multidrug resistant (MDR) while the remaining isolates were susceptible. Significant associations were discovered between the hld gene with CA-MSSA (p=0.016) p =0.016) and the seo gene with HA-MSSA (p=0.023). p =0.023). However, there is no significant association between virulence genes among the different types of infection. The clinical MSSA isolates in Terengganu showed high prevalence and high diversity of virulence gene carriage.
| Item Type: | Article |
|---|---|
| Funders: | Malaysian Ministry of Higher Education (RAGS/1/2015/SKK0/UNISZA/02/1); (FRGS/1/2019/SKK11/UNISZA/02/1) |
| Uncontrolled Keywords: | Methicillin-susceptible Staphylococcus aureus; virulence genes; CA-MSSA; HA-MSSA |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Biomedical Science Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 22 Nov 2024 01:26 |
| Last Modified: | 22 Nov 2024 01:26 |
| URI: | http://eprints.um.edu.my/id/eprint/47086 |
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