Lim, Sharoen Yu Ming and Pan, Yan and Alshagga, Mustafa and Lim, Willone and Cin, Kong and Alshehade, Salah A. and Alshawsh, Mohammed (2024) CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan. Journal of Applied Toxicology, 44 (11). pp. 1647-1656. ISSN 0260-437X, DOI https://doi.org/10.1002/jat.4597.
Full text not available from this repository.Abstract
CYP-14 members of the Caenorhabditis elegans (C. elegans) Cytochrome P450 (CYP) enzyme family, plays important roles in mitochondrial dysfunction, detoxification, lipid metabolism, defense and lifespan regulation. The review identifies CYP-14 members: cyp-14A1, cyp-14A2, cyp-14A3, cyp-14A4, cyp-14A5 and their homology with human CYP families. Despite limited studies on C. elegans cyp-14 members, the findings unraveled their complex crosstalk between mitochondrial stress, detoxification mechanisms, and lifespan regulation, emphasizing the complexity of these interconnected pathways as well as how their regulation depends on environmental cues changes including pH, nutrients, ROS and chemical stressors. The review underscores the translational relevance to human health, shedding light on potential human homologues and their implications in age-related, metabolic and respiratory diseases. Among other genes, cyp-14A2 and cyp-14A4 predominate the mitochondrial function, heat resistance, lipid metabolism, detoxification and lifespan pathways. In conclusion, these insights pave the way for future research, offering promising avenues for therapeutic interventions targeting CYP-14 activity to address age-related diseases and promote healthy aging.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | age-related; C. elegans; cyp-14; cyp-14A; mitochondrial dysfunction |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 07 Jan 2025 08:59 |
| Last Modified: | 07 Jan 2025 08:59 |
| URI: | http://eprints.um.edu.my/id/eprint/47021 |
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