Hamrayev, Hemra and Jazayeri, Seyed Davoud and Yusefi, Mostafa and Brianna, - and Teow, Sin-Yeang and Wu, Yuan Seng and Anwar, Ayaz and Korpayev, Serdar and Kartouzian, Aras and Shameli, Kamyar (2024) Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity. Particle & Particle Systems Characterization, 41 (8). ISSN 0934-0866, DOI https://doi.org/10.1002/ppsc.202400009.
Full text not available from this repository.Abstract
In this study, zinc oxide nanoparticles (ZnO-NPs) are synthesized and combined with chitosan (Cs) to create Cs/ZnO-NPs nanomicelles, aiming to investigate their potential as a novel cancer treatment. The ZnO-NPs are produced through a sintering process at temperatures ranging from 300 to 700 degrees C. The most effective nanoparticles are obtained at 600 degrees C, as determined by X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses, which confirmed their crystallinity and purity. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) are employed to characterize the size and shape of the nanoparticles, revealing predominantly spherical and hexagonal structures with stable dimensions. The cytotoxic effects of the Cs/ZnO-NPs are evaluated against various cancer cell types. The results show that at a concentration of 125 mu g mL-1, the Cs/ZnO-NPs demonstrate significantly higher cancer cell toxicity compared to ZnO-NPs alone, while remaining non-toxic to normal cells. This indicates that Cs/ZnO-NPs have a superior ability to selectively target cancer cells. These findings suggest that Cs/ZnO-NPs nanomicelles hold promise as an effective and safe nanotherapeutic approach in the realm of cancer treatment, meriting further exploration for clinical applications. Pioneering a novel cancer therapy, this research utilizes Cs/ZnO-NPs nanomicelles, showcasing heightened selective toxicity against cancer cells while safeguarding healthy ones. These results open promising paths for safer, more effective cancer treatments, potentially transforming oncological approaches and inspiring advancements in future nanomedicine. image
| Item Type: | Article |
|---|---|
| Funders: | Takasago Thermal Engineering Co. Ltd. (130000.7343.4B422) |
| Uncontrolled Keywords: | cancer treatment; cytotoxicity; innovative therapy; nanomedicine; ZnO nanoparticles |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 08 Jan 2025 08:47 |
| Last Modified: | 08 Jan 2025 08:47 |
| URI: | http://eprints.um.edu.my/id/eprint/47005 |
Actions (login required)
 |
View Item |
