Yow, Hui-Yin and Ikawati, Muthi and Siswanto, Soni and Hermawan, Adam and Rahmat, Alim Khodimul and Tan, Janet Sui-Ling and Tee, Ying-Chew and Ng, Kok-Peng and Ikawati, Zullies (2024) Influence of genetic polymorphisms on pharmacokinetics and treatment response of mycophenolic acid: a scoping review. Pharmacogenomics, 25 (5-6). pp. 259-288. ISSN 1462-2416, DOI https://doi.org/10.1080/14622416.2024.2344430.
Full text not available from this repository.Abstract
This scoping review explores the impact of genetic polymorphisms on the pharmacokinetics and treatment responses of mycophenolic acid (MPA), an immunosuppressant. The study includes 83 articles from 1226 original studies, focusing on transplantation (n = 80) and autoimmune disorders (n = 3). Genetic variants in uridine 5 `-diphospho-glucuronosyltransferase (UGT1A9, UGT1A8 and UGT2B7) and transmembrane transporters (ABCC2, SLCO1B1, SLCO1B3 and ABCB1) significantly affected MPA's pharmacokinetics and susceptibility to its adverse effect. Whereas variants in several genes including UGT1A9, UGT2B7, IMPDH1 and IMPDH2 have been associated with a higher risk of transplant rejection. However, there is a lack of studies on MPA's impact on autoimmune disorders and limited research on the Asian population. The findings underscore the need for further research on MPA's impact across different populations and diseases, particularly among other Asian ethnic groups, to advance personalized medicine in MPA therapy.
| Item Type: | Article |
|---|---|
| Funders: | SATU Joint Research Scheme Program Universiti Malaya International Collaboration Grant, Universiti of Malaya, Malaysia and Universitas Gadjah Mada, Indonesia |
| Uncontrolled Keywords: | immunosuppressant; mycophenolic acid; pharmacogenomics; polymorphisms |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine Faculty of Pharmacy > Department of Pharmaceutical Life Sciences Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Jan 2025 02:23 |
| Last Modified: | 13 Jan 2025 02:23 |
| URI: | http://eprints.um.edu.my/id/eprint/46939 |
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