Nishadani, D. K. S. and Gunathilake, Thennakoon M. Sampath Udeni and Ching, Yern Chee and Noothalapati, Hemanth (2024) Carboxymethyl cellulose hydrogel for pH-responsive drug release of curcumin. Iranian Polymer Journal, 33 (10). pp. 1449-1467. ISSN 1026-1265, DOI https://doi.org/10.1007/s13726-024-01331-8.
Full text not available from this repository.Abstract
This study outlines the development of a pH-sensitive hydrogel for hydrophobic drug delivery by cross-linking carboxymethyl cellulose (CMC) with varying fumaric acid (FA) concentrations (9%-26%). FTIR analysis of CMC-FA-26% hydrogel showed a prominent band at 1714 cm-1, indicating the formation of ester bond. Compression tests demonstrated increased strength with cross-linking density changing from 9 to 26%. Stress-strain analysis revealed plastic deformation beyond 80% strain, with compression stress rising from 0.12 +/- 0.1 to 1.9 +/- 0.1 MPa as FA content increased from 9 to 26%. Thermogravimetric analysis revealed higher weight reduction (25-28%) for CMC-FA-26% compared to CMC-FA-9% (16-18%) during the fumaric acid weight loss stage. Scanning electron microscopic (SEM) examination showed that the hydrogels had a porous structure, crucial for their swelling, drug loading, and release. According to the swelling results, swellability was decreased by increasing cross-linking degree, and increased by increasing pH values. In the biodegradability test, the CMC-FA-26% hydrogel showed 35% weight loss after 28 days, while the CMC-FA-9% hydrogel exhibited a 54% weight loss. To improve the compatibility between hydrophilic CMC and hydrophobic curcumin (CUR)/beta-cyclodextrin (beta-CD) was incorporated to the hydrogel. The solubility results showed that with varying the molar ratio of CUR:beta-CD from 1:1 to 1:3, the mean UV-Vis absorption changed from 0.005 to 1.048. The variation of the medium's pH from 1.2 to 12 resulted in a notable increase in the cumulative curcumin release, ranging from 5.91 to 46.63%. Drug delivery results indicated excellent drug release in alkaline medium, highlighting the hydrogel's potential for targeted drug delivery of hydrophobic drugs in the gastrointestinal tract.
| Item Type: | Article |
|---|---|
| Funders: | Department of Polymer Science, Faculty of Applied Science, University of Sri Jayewardenepura |
| Uncontrolled Keywords: | Carboxymethyl cellulose; Fumaric acid; Controlled drug delivery; Hydrophobic drug; pH sensitivity |
| Subjects: | T Technology > TD Environmental technology. Sanitary engineering T Technology > TP Chemical technology |
| Divisions: | Faculty of Engineering > Department of Chemical Engineering Deputy Vice Chancellor (Research & Innovation) Office > Centre for Research in Biotechnology for Agriculture |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Jan 2025 05:07 |
| Last Modified: | 14 Jan 2025 05:07 |
| URI: | http://eprints.um.edu.my/id/eprint/46933 |
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