Chua, H. S. and Soh, Y. H. and Ibrahim, S. and Abdullah, N. H. and Seri, N. A. A. Che Mat and AbuBakar, S. and Loong, S. K. (2024) Novel Vibrio vulnificus sequence type 540 infection in a hepatitis patient. Tropical Biomedicine, 41 (2). pp. 220-223. ISSN 0127-5720, DOI https://doi.org/10.47665/tb.41.2.014.
Full text not available from this repository.Abstract
Vibrio vulnificus infection is associated with high morbidity and mortality in high-risk patients. Poor prognoses could lead to >50% mortality rate. The present report describes a case of V. vulnificus bacteremia in a cirrhotic patient with underlying hepatitis C. He presented with generalised abdominal pain associated with distention and could not ambulate for one week. He also complained of fever for six days and pruritus for 10 days. Tea-coloured urine was noted in continuous bag drainage. The abdomen was distended but soft, with mild tenderness palpated over the left lumbar and iliac region. Blood investigation indicated ongoing infection and inflammation. The aerobic blood culture was identified using the matrix-assisted laser desorption/ionisation-time of flight mass spectrometry and confirmed via 16S rDNA sequencing as V. vulnificus. . Multilocus sequence typing of the isolated V. vulnificus revealed a novel sequence type, ST540. The patient responded well to the intravenous cefoperazone and was then discharged with a four day-course of oral ciprofloxacin, 500 mg twice daily after completing the intravenous cefoperazone for 10 days. Clinical history and physical examination are important for early antibiotic therapy initiation and appropriate surgical intervention. Furthermore, bacterial strain typing is also essential for epidemiological surveillance and potentially anticipating the pathogen's virulence traits, which are vital in controlling and preventing the spread of infection.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia under Dana Langganan Sukuk Pakej Rangsangan Ekonomi Prihatin Rakyat (SUKUK PRIHATIN) -Fasa 2 (MO002-2021) |
| Uncontrolled Keywords: | Infectious disease; Malaysia; MALDI-TOF; multilocus sequence typing; 16S rDNA |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Social & Preventive Medicine Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Jan 2025 07:55 |
| Last Modified: | 15 Jan 2025 07:55 |
| URI: | http://eprints.um.edu.my/id/eprint/46913 |
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