Kizhakkoottu, Suvarna and Ramani, Pratibha and Tilakaratne, Wanninayake Mudiyanselage (2024) Role of Stem Cells in the Pathogenesis and Malignant Transformation of Oral Submucous Fibrosis. Stem Cell Reviews and Reports, 20 (6). pp. 1512-1520. ISSN 2629-3269, DOI https://doi.org/10.1007/s12015-024-10744-0.
Full text not available from this repository.Abstract
BackgroundPathogenesis and malignant potential of Oral submucous fibrosis(OSMF) have always been a topic of interest among the researchers. Despite OSMF being a collagen metabolic disorder, the alterations occurring in the connective tissue stroma affects the atrophic surface epithelium in later stages and progresses to malignant phenotypes. The present review aims to summarize the role of stem cells in the pathogenesis and malignant transformation of oral submucous fibrosis.Materials and MethodsA literature search was carried out using data banks like Medline and Embase, google scholar and manual method with no time frame, pertinent to the role of mucosal stem cells in OSMF and its malignisation. The relevant literature was reviewed, critically appraised by all the authors and compiled in this narrative review.ResultsCritical appraisal and evaluation of the data extracted from the selected articles were compiled in this review. The collated results highlighted the upregulation and downregulation of various stem cell markers during the progression and malignisation of OSMF were depicted in a descriptive and detail manner in the present review.ConclusionWe highlight the potential of mucosal stem cells in the regulation and malignisation of OSMF. However, future large-scale clinical studies will be needed to support whether manipulation of this stem cells at molecular level will be sufficient for the treatment and preventing the malignant transformation of OSMF.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Stem Cells; Oral Submucous Fibrosis; OSMF; Malignant Transformation of OSMF |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Department of Oral & Maxillofacial Clinical Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Jan 2025 07:40 |
| Last Modified: | 15 Jan 2025 07:40 |
| URI: | http://eprints.um.edu.my/id/eprint/46909 |
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