Misnan, Norazlan Mohmad and Afzan, Adlin and Omar, Maizatul Hasyima and Low, Kah Hin (2024) Flavonoid Variability in Carica papaya L. var. Sekaki Leaf Maturation and Its Association With Sexual Differentiation Using Targeted Metabolomics. Natural Product Communications, 19 (7). 1934578X241260175. ISSN 1934-578X, DOI https://doi.org/10.1177/1934578X241260175.
Full text not available from this repository.Abstract
Background: Carica papaya L. is a dioecious plant with leaves known for their medicinal and nutritional value due to their rich phytochemical content, including flavonoids. Phytochemical variability arising from plant maturity and sex differences may influence the bioactivity of the plant. Objectives: This research aims to investigate the variations of flavonoids in C. papaya leaves across different maturation stages and the impact of sex differences on the accumulation of these compounds. Methods: An ultra-high performance liquid chromatography-tandem mass spectrometry method was developed to quantify 6 flavonoids (manghaslin, clitorin, rutin, nicotiflorin, quercetin, and isorhamnetin) in the leaves simultaneously. The acquired data were further analyzed using chemometric tools. Results: Significantly higher concentrations of flavonoids were observed in shoots and young leaves in comparison to older leaves. Furthermore, distinct variations in flavonoid composition between male and female plants were also observed, especially in young leaves, as evidenced by hierarchical clustering analysis. Further analysis of flavonoid content indicates that clitorin, nicotiflorin, and rutin could serve as chemical markers to differentiate maturation stages and sexes. Conclusion: The study revealed significant variations in flavonoid concentrations during leaf development and between male and female plants, highlighting the importance of understanding these differences for unlocking the full potential of C. papaya leaves in medical and nutritional applications.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Health Malaysia (NMRR-14-569-21235) |
| Uncontrolled Keywords: | Carica papaya; flavonoids; maturation stages; sex differences; ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 25 Mar 2025 01:42 |
| Last Modified: | 25 Mar 2025 01:42 |
| URI: | http://eprints.um.edu.my/id/eprint/46856 |
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