Alagasamy, Sangeeta Vani and Fuloria, Shivkanya and Franklin, Freddy and Raju, Chandramathi Samudi and Jagadeesan, Dharshini and Sa'ad, Mohammad Auwal and Veerasamy, Ravichandran and Subramaniyan, Vetriselvan and Wu, Yuan Seng and Karupiah, Sundram and Fuloria, Neeraj Kumar (2024) Synthesis and dengue inhibition potential of new uridine derivatives: The DENV 2 inhibitors. Pakistan Journal of Pharmaceutical Sciences, 37 (4). pp. 753-759. ISSN 1011-601X, DOI https://doi.org/10.36721/PJPS.2024.37.4.REG.753-759.1.
Full text not available from this repository.Abstract
Dengue is an important arboviral infection worldwide for which presently there is no specific medicine. Evidence suggests there are four serotypes of dengue virus (DENV1-4), of which DENV 2 is considered to cause the most sever dengue. Therefore, this study was aimed to develop the new uridine derivatives (NUDs) against dengue virus (DENV 2). In current study 2-(3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-4-((substituted cyclohexa-2,5dienylidene)methyl)-1,2,4-triazine-3,5-(2H,4H)-dione (2a-f), were obtained via reaction of substituted uridine (1) and different aromatic aldehydes separately. Synthesized NUDs were further characterized using FTIR, 1H & 13C-NMR, mass, and element analysis data. Characterized NUDs were assessed for their inhibition potential against DENV 2. Synthesized NUDs were also evaluated for their cytotoxicity towards Vero cells by MTT assay method. This investigation successfully synthesized NUDs 2a-f and reported their high inhibitory activity against DENV 2. The synthesized NUDs exhibited negligible cytotoxicity. High anti-viral activity against DENV 2 serotype and least/no cytotoxicity of NUDs suggests their importance in the treatment of dengue. Present study recommends that in future these NUDs must be investigated for their clinical importance to establish them as a choice for dengue treatment.
| Item Type: | Article |
|---|---|
| Funders: | Science and Technology Development Fund (STDF) Ministry of Higher Education & Scientific Research (MHESR) Ministry of Higher Education, Research & Innovation, Oman (FRGS/1/2018/SKK06/AIMST/02/3) |
| Uncontrolled Keywords: | Dengue; DENV 2; nucleoside; antiviral; uridine; enamines |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine > Medical Microbiology Department Faculty of Medicine > Parasitology Deparment |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 25 Mar 2025 02:53 |
| Last Modified: | 25 Mar 2025 02:53 |
| URI: | http://eprints.um.edu.my/id/eprint/46840 |
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