Aborziza, Mohamed and Amalia, Riezki and Zuhrotun, Ade and Ikram, Nur Kusaira Khairul and Novitasari, Dhania and Muchtaridi, Muchtaridi (2024) Coffee Bean and Its Chemical Constituent Caffeine and Chlorogenic Acid as Promising Chemoprevention Agents: Updated Biological Studies against Cancer Cells. Molecules, 29 (14). p. 3302. ISSN 1420-3049, DOI https://doi.org/10.3390/molecules29143302.
Full text not available from this repository.Abstract
Cancer is a complicated and ever-evolving disease that remains a significant global cause of disease and mortality. Its complexity, which is evident at the genetic and phenotypic levels, contributes to its diversity and resistance to treatment. Numerous scientific investigations on human and animal models demonstrate the potential of phytochemicals in cancer prevention. Coffee has been shown to possess potent anti-carcinogenic properties, and studies have documented the consumption of coffee as a beverage reduces the risk of cancer occurrence. The major secondary metabolites of coffee, named caffeine and chlorogenic acid, have been linked to anti-inflammatory and antineoplastic effects through various signaling. In light of this, this review article provides a comprehensive analysis based on studies in anticancer effects of coffee, chlorogenic acid, and caffeine published between 2010 and 2023, sourced from Scopus, Pubmed, and Google Scholar databases. We summarize recent advances and scientific evidence on the association of phytochemicals found in coffee with a special emphasis on their biological activities against cancer and their molecular mechanism deemed potential to be used as a novel therapeutic target for cancer prevention and therapy.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Research and Technology of the Republic of Indonesia (RISTEK) (1503/UN6.3.1/PT.00/2024) |
| Uncontrolled Keywords: | coffee; caffeine; chlorogenic acid; chemopreventive; autophagy; tumor cells |
| Subjects: | Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 25 Mar 2025 02:42 |
| Last Modified: | 25 Mar 2025 02:42 |
| URI: | http://eprints.um.edu.my/id/eprint/46837 |
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