Abd Halim, Nur Farah Anis and Ab Aziz, Atiqah and Tan, Sik-Loo and Selvaratnam, Veenesh and Kamarul, Tunku (2024) A Systematic Review of Human Amnion Enhanced Cartilage Regeneration in Full-Thickness Cartilage Defects. Biomimetics, 9 (7). p. 383. ISSN 2313-7673, DOI https://doi.org/10.3390/biomimetics9070383.
Full text not available from this repository.Abstract
Cartilage defects present a significant challenge in orthopedic medicine, often leading to pain and functional impairment. To address this, human amnion, a naturally derived biomaterial, has gained attention for its potential in enhancing cartilage regeneration. This systematic review aims to evaluate the efficacy of human amnion in enhancing cartilage regeneration for full-thickness cartilage defects. An electronic search was conducted on MEDLINE-PubMed, Web of Science (WoS), and the Scopus database up to 27 December 2023 from 2007. A total of 401 articles were identified. After removing 125 duplicates and excluding 271 articles based on predetermined criteria, only 5 articles remained eligible for inclusion in this systematic review. All five eligible articles conducted in vivo studies utilizing rabbits as subjects. Furthermore, analysis of the literature reveals an increasing trend in the frequency of utilizing human amnion for the treatment of cartilage defects. Various forms of human amnion were utilized either alone or seeded with cells prior to implantation. Histological assessments and macroscopic observations indicated usage of human amnion improved cartilage repair outcomes. All studies highlighted the positive results despite using different forms of amnion tissues. This systematic review underscores the promising role of human amnion as a viable option for enhancing cartilage regeneration in full-thickness cartilage defects, thus offering valuable insights for future research and clinical applications in orthopedic tissue engineering.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education Malaysia via Prototype Research, National Orthopaedic Centre of Excellence for Research & Learning (NOCERAL) |
| Uncontrolled Keywords: | human amnion; cartilage regeneration; cartilage defect; orthopedics |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Orthopaedic Surgery Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 25 Mar 2025 02:59 |
| Last Modified: | 25 Mar 2025 02:59 |
| URI: | http://eprints.um.edu.my/id/eprint/46835 |
Actions (login required)
 |
View Item |
