Edirisuriya, Tharushi N. and Gunathilake, Thennakoon M. Sampath Udeni and Ching, Yern Chee and Noothalapati, Hemanth (2024) Curcumin Targeted Drug Delivery Using Iron Oxide Nanoparticle Incorporated Magnetic Responsive Carboxymethyl Cellulose Hydrogel. Polymer Science Series B, 66 (2). pp. 213-226. ISSN 1560-0904, DOI https://doi.org/10.1134/S1560090424600542.
Full text not available from this repository.Abstract
In recent years, magnetic-responsive hydrogels, alongside other smart hydrogel materials, have emerged as a focal point of research owing to their exceptional responsive properties and their wide array of biomedical applications. This study introduces an innovative approach involving the use of a biocompatible, carboxymethyl cellulose (CMC) hydrogel crosslinked with non-toxic fumaric acid and loaded with iron oxide nanoparticles (Fe3O4) as a novel carrier for magnetic-responsive curcumin drug delivery. Structural characterization of the CMC hydrogel and Fe3O4 nanoparticles was conducted through rigorous analysis, utilizing techniques such as Fourier-transform infrared spectroscopy, scanning electron microscopy, and dynamic light scattering. Our results indicate an intriguing inverse relationship between Fe3O4 nanoparticle concentration and the swelling ratio of the hydrogel, revealing an interesting relationship between nanoparticle concentration and hydrogel properties. Furthermore, our investigation revealed that the 3.3% Fe3O4-loaded magnetic CMC hydrogel exhibited a notably higher curcumin release percentage in comparison to other magnetic CMC hydrogel formulations. This underscores the efficacy of our magnetic CMC hydrogel nanocomposite as a vehicle for curcumin drug delivery, especially when subjected to external magnetic field stimulation. Significantly, our data substantiates that the presence of Fe3O4 nanoparticles within the hydrogel network results in a sustained and prolonged release of curcumin when exposed to magnetic stimulation and underscores the potential of magnetic CMC hydrogel nanocomposites as a promising platform for controlled drug delivery.
| Item Type: | Article |
|---|---|
| Funders: | Department of Polymer Science, Faculty of Applied Science, University of Sri Jayewardenepura, Department of Physics, Faculty of Applied Science, University of Sri Jayewardenepura |
| Subjects: | T Technology > TP Chemical technology |
| Divisions: | Faculty of Engineering Faculty of Engineering > Department of Chemical Engineering |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 25 Mar 2025 02:55 |
| Last Modified: | 25 Mar 2025 02:55 |
| URI: | http://eprints.um.edu.my/id/eprint/46834 |
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