Arends, Samuel and Drenthen, Judith and de Koning, Laura and van den Bergh, Peter and Hadden, Robert D. M. and Kuwabara, Satoshi and Reisin, Ricardo C. and Shahrizaila, Nortina and Ajroud-Driss, Senda and Antonini, Giovanni and Attarian, Shahram and Balducci, Claudia and Bertorini, Tulio and Brannagan, Thomas H. and Cavaletti, Guido and Chao, Chi-Chao and Chavada, Govind and Dillmann, Klaus-Ulrich and Dimachkie, Mazen M. and Galassi, Giuliana and Gutierrez-Gutierrez, Gerardo and Harbo, Thomas and Islam, Badrul and Islam, Zhahirul and Katzberg, Hans and Kusunoki, Susumu and Manganelli, Fiore and Miller, James A. L. and Pardo, Julio and Pereon, Yann and Rajabally, Yusuf A. and Sindrup, Soren and Stettner, Mark and Uncini, Antonino and Verhamme, Camiel and Vytopil, Michal and Waheed, Waqar and Jacobs, Bart C. and Cornblath, David R. and Consortium, IGOS (2024) Electrodiagnostic subtyping in Guillain-Barre syndrome patients in the International Guillain-Barre Outcome Study. European Journal of Neurology, 31 (9). ISSN 1351-5101, DOI https://doi.org/10.1111/ene.16335.
Full text not available from this repository.Abstract
Background and purpose: Various electrodiagnostic criteria have been developed in Guillain-Barr & eacute; syndrome (GBS). Their performance in a broad representation of GBS patients has not been evaluated. Motor conduction data from the International GBS Outcome Study (IGOS) cohort were used to compare two widely used criterion sets and relate these to diagnostic amyotrophic lateral sclerosis criteria. Methods: From the first 1500 patients in IGOS, nerve conduction studies from 1137 (75.8%) were available for the current study. These patients were classified according to nerve conduction studies criteria proposed by Hadden and Rajabally. Results: Of the 1137 studies, 68.3% (N = 777) were classified identically according to criteria by Hadden and Rajabally: 111 (9.8%) axonal, 366 (32.2%) demyelinating, 195 (17.2%) equivocal, 35 (3.1%) inexcitable and 70 (6.2%) normal. Thus, 360 studies (31.7%) were classified differently. The areas of differences were as follows: 155 studies (13.6%) classified as demyelinating by Hadden and axonal by Rajabally; 122 studies (10.7%) classified as demyelinating by Hadden and equivocal by Rajabally; and 75 studies (6.6%) classified as equivocal by Hadden and axonal by Rajabally. Due to more strictly defined cutoffs fewer patients fulfilled demyelinating criteria by Rajabally than by Hadden, making more patients eligible for axonal or equivocal classification by Rajabally. In 234 (68.6%) axonal studies by Rajabally the revised El Escorial (amyotrophic lateral sclerosis) criteria were fulfilled; in axonal cases by Hadden this was 1.8%. Conclusions and discussion: This study shows that electrodiagnosis in GBS is dependent on the criterion set utilized, both of which are based on expert opinion. Reappraisal of electrodiagnostic subtyping in GBS is warranted.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | amyotrophic lateral sclerosis; electrodiagnosis; Guillain-Barr & eacute; syndrome; nerve conduction studies; polyneuropathy |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 25 Mar 2025 03:12 |
| Last Modified: | 25 Mar 2025 03:12 |
| URI: | http://eprints.um.edu.my/id/eprint/46831 |
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