Tey, Siew Ling and Chee, Winnie S. S. and Deerochanawong, Chaicharn and Berde, Yatin and Lim, Lee-Ling and Boonyavarakul, Apussanee and Wakefield, Brittany and Baggs, Geraldine and Huynh, Dieu Thi Thu (2024) Diabetes-specific formula with standard of care improves glycemic control, body composition, and cardiometabolic risk factors in overweight and obese adults with type 2 diabetes: results from a randomized controlled trial. Frontiers in Nutrition, 11. p. 1400580. ISSN 2296-861X, DOI https://doi.org/10.3389/fnut.2024.1400580.
Full text not available from this repository.Abstract
Background and aims: Medical nutrition therapy is important for diabetes management. This randomized controlled trial investigated the effects of a diabetes-specific formula (DSF) on glycemic control and cardiometabolic risk factors in adults with type 2 diabetes (T2D). Methods: Participants (n = 235) were randomized to either DSF with standard of care (SOC) (DSF group; n = 117) or SOC only (control group; n = 118). The DSF group consumed one or two DSF servings daily as meal replacement or partial meal replacement. The assessments were done at baseline, on day 45, and on day 90. Results: There were significant reductions in glycated hemoglobin (-0.44% vs. -0.26%, p = 0.015, at day 45; -0.50% vs. -0.21%, p = 0.002, at day 90) and fasting blood glucose (-0.14 mmol/L vs. +0.32 mmol/L, p = 0.036, at day 90), as well as twofold greater weight loss (-1.30 kg vs. -0.61 kg, p < 0.001, at day 45; -1.74 kg vs. -0.76 kg, p < 0.001, at day 90) in the DSF group compared with the control group. The decrease in percent body fat and increase in percent fat-free mass at day 90 in the DSF group were almost twice that of the control group (1.44% vs. 0.79%, p = 0.047). In addition, the percent change in visceral adipose tissue at day 90 in the DSF group was several-fold lower than in the control group (-6.52% vs. -0.95%, p < 0.001). The DSF group also showed smaller waist and hip circumferences, and lower diastolic blood pressure than the control group (all overall p <= 0.045). Conclusion: DSF with SOC yielded significantly greater improvements than only SOC in glycemic control, body composition, and cardiometabolic risk factors in adults with T2D.
| Item Type: | Article |
|---|---|
| Funders: | Abbott Nutrition10.13039/100011947, Phramongkutklao Hospital |
| Uncontrolled Keywords: | type 2 diabetes; nutrition therapy; meal replacement; diabetes-specific formula; glycemic control; body composition; cardiometabolic risk factors |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 25 Mar 2025 06:13 |
| Last Modified: | 25 Mar 2025 06:13 |
| URI: | http://eprints.um.edu.my/id/eprint/46821 |
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