Tan, Mei Sze and Cheah, Phaik-Leng and Chin, Ai-Vyrn and Looi, Lai -Meng and Chang, Siow-Wee (2024) A multi-ethnic proteomic profiling analysis in Alzheimer's disease identifies the disparities in dysregulation of proteins and pathogenesis. PeerJ, 12. e17643. ISSN 2167-8359, DOI https://doi.org/10.7717/peerj.17643.
Full text not available from this repository.Abstract
Background: Alzheimer ` s disease (AD) is the most common type of dementia that affects the elderly population. Lately, blood-based proteomics have been intensively sought in the discovery of AD biomarkers studies due to the capability to link external environmental factors with the development of AD. Demographic differences have been shown to affect the expression of the proteins in different populations which play a vital role in the degeneration of cognitive function. Method: In this study, a proteomic study focused on Malaysian Chinese and Malay prospects was conducted. Differentially expressed proteins (DEPs) in AD patients and normal controls for Chinese and Malays were identi fi ed. Functional enrichment analysis was conducted to further interpret the biological functions and pathways of the DEPs. In addition, a survey investigating behavioural practices among Chinese and Malay participants was conducted to support the results from the proteomic analysis. Result: The variation of dysregulated proteins identi fi ed in Chinese and Malay samples suggested the disparities of pathways involved in this pathological condition for each respective ethnicity. Functional enrichment analysis supported this assumption in understanding the protein-protein interactions of the identi fi ed protein signatures and indicate that differentially expressed proteins identi fi ed from the Chinese group were signi fi cantly enriched with the functional terms related to A beta /tau protein-related processes, oxidative stress and in fl ammation whereas neuroin fl ammation was associated with the Malay group. Besides that, a signi fi cant difference in sweet drinks/food intake habits between these two groups implies a relationship between sugar levels and the dysregulation of protein APOA4 in the Malay group. Additional meta-analysis further supported the dysregulation of proteins TF, AHSG , A1BG , APOA4 and C4A among AD groups. Conclusion: These fi ndings serve as a preliminary understanding in the molecular and demographic studies of AD in a multi-ethnic population.
| Item Type: | Article |
|---|---|
| Funders: | UM International Collaboration Grant (ST041-2022), Ministry of Education, Malaysia (FRGS/1/2019/SKK06/UM/02/5) |
| Uncontrolled Keywords: | Alzheimer ` s disease (AD); Blood-biomarkers; Multi-ethnics; Proteomics; Dysregulated proteins |
| Subjects: | Q Science > QH Natural history R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Pathology Department Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 Mar 2025 08:22 |
| Last Modified: | 26 Mar 2025 08:22 |
| URI: | http://eprints.um.edu.my/id/eprint/46804 |
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