Teh, Huey Xhin and Phang, Shou Jin and Neo, Yun Ping and Looi, Mee Lee and Kuppusamy, Umah Rani and Arumugam, Bavani (2024) Fabrication and characterization of Ecklonia cava phlorotannin-loaded PVA/PVP blend electrospun nanofibers as a potential diabetic wound dressing biomaterial. Journal of Applied Polymer Science, 141 (39). ISSN 0021-8995, DOI https://doi.org/10.1002/app.56016.
Full text not available from this repository.Abstract
Diabetic wound healing remains a challenging issue, necessitating advanced dressings with active therapeutic agents to reduce inflammation and promote healing. Ecklonia cava phlorotannin (ECP) possesses therapeutic potential for wound healing including anti-microbial, antioxidant, and anti-inflammatory properties. Our previous study demonstrates the therapeutic efficacy of ECP-loaded nanofibers in an in vitro hyperglycemic wound model. The present paper focuses on the detailed characterization of the polyvinyl alcohol (PVA)/polyvinylpyrrolidone (PVP) blend nanofiber incorporated with ECP. The ideal ratio, PVA80:PVP20, is selected to incorporate with ECP via the blend electrospinning method. To confirm the successful loading of ECP (0.5% and 1%), physicochemical characterization is conducted using scanning electron microscopy, Fourier-transform infrared spectroscopy, and thermal analysis. Functionality assays are performed to evaluate their applicability as dressing biomaterials. Physicochemical analyses confirm the successful loading of ECP into the nanofibers. Overall, the ECP-loaded PVA/PVP nanofiber membranes exhibit favorable wound dressing criteria, which attributed to high water absorption capacity (200%-400%), sufficient water vapor transmission rate (1550-1650 g/m2/d), high loading efficiency and slow release. Bioactivity tests indicate that the ECP's effectiveness is unaffected by the electrospinning process. Importantly, these membranes exhibit biocompatibility and nontoxicity to human dermal fibroblasts, indicating their potential as good diabetic wound dressings.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education Malaysia under the Fundamental Research Grant Scheme (FRGS/1/2019/SKK08/UM/02/29) |
| Uncontrolled Keywords: | diabetic wound; Ecklonia cava; electrospinning; wound dressing |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Biomedical Science Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 Mar 2025 08:31 |
| Last Modified: | 26 Mar 2025 08:31 |
| URI: | http://eprints.um.edu.my/id/eprint/46799 |
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