Tan, Foo Hou and Sukri, Asif and Idris, Nuryana and Ong, Kien Chai and Schee, Jie Ping and Tan, Chong Tin and Tan, Soon Hao and Wong, Kum Thong and Wong, Li Ping and Tee, Kok Keng and Chang, Li-Yen (2024) A systematic review on Nipah virus: global molecular epidemiology and medical countermeasures development. Virus Evolution, 10 (1). veae048. ISSN 2057-1577, DOI https://doi.org/10.1093/ve/veae048.
Full text not available from this repository.Abstract
Nipah virus (NiV) is an emerging pathogen that causes encephalitis and a high mortality rate in infected subjects. This systematic review aimed to comprehensively analyze the global epidemiology and research advancements of NiV to identify the key knowledge gaps in the literature. Articles searched using literature databases, namely PubMed, Scopus, Web of Science, and Science Direct yielded 5,596 articles. After article screening, 97 articles were included in this systematic review, comprising 41 epidemiological studies and 56 research developments on NiV. The majority of the NiV epidemiological studies were conducted in Bangladesh, reflecting the country's significant burden of NiV outbreaks. The initial NiV outbreak was identified in Malaysia in 1998, with subsequent outbreaks reported in Bangladesh, India, and the Philippines. Transmission routes vary by country, primarily through pigs in Malaysia, consumption of date palm juice in Bangladesh, and human-to-human in India. However, the availability of NiV genome sequences remains limited, particularly from Malaysia and India. Mortality rates also vary according to the country, exceeding 70% in Bangladesh, India, and the Philippines, and less than 40% in Malaysia. Understanding these differences in mortality rate among countries is crucial for informing NiV epidemiology and enhancing outbreak prevention and management strategies. In terms of research developments, the majority of studies focused on vaccine development, followed by phylogenetic analysis and antiviral research. While many vaccines and antivirals have demonstrated complete protection in animal models, only two vaccines have progressed to clinical trials. Phylogenetic analyses have revealed distinct clades between NiV Malaysia, NiV Bangladesh, and NiV India, with proposals to classify NiV India as a separate strain from NiV Bangladesh. Taken together, comprehensive OneHealth approaches integrating disease surveillance and research are imperative for future NiV studies. Expanding the dataset of NiV genome sequences, particularly from Malaysia, Bangladesh, and India will be pivotal. These research efforts are essential for advancing our understanding of NiV pathogenicity and for developing robust diagnostic assays, vaccines and therapeutics necessary for effective preparedness and response to future NiV outbreaks.
| Item Type: | Article |
|---|---|
| Funders: | CEPI grant (IF069-2022), Universiti Malaya grant (MG007-2021) |
| Uncontrolled Keywords: | Nipah virus; disease outbreaks; vaccine development; animal models; antivirals |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Biomedical Science Department Faculty of Medicine > Medical Microbiology Department Faculty of Medicine > Medicine Department Faculty of Medicine > Pathology Department Faculty of Medicine > Social & Preventive Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 10 Apr 2025 03:19 |
| Last Modified: | 10 Apr 2025 03:19 |
| URI: | http://eprints.um.edu.my/id/eprint/46695 |
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