Bashiri, Zahra and Sharifi, Ali Mohammad and Ghafari, Mozhdeh and Hosseini, Seyed Jamal and Shahmahmoodi, Zeinab and Moeinzadeh, Alaa and Parsaei, Houman and Khadivi, Farnaz and Afzali, Azita and Koruji, Morteza (2024) In-vitro and in-vivo evaluation of angiogenic potential of a novel lithium chloride loaded silk fibroin / alginate 3D porous scaffold with antibacterial activity, for promoting diabetic wound healing. International Journal of Biological Macromolecules, 277 (4). p. 134362. ISSN 0141-8130, DOI https://doi.org/10.1016/j.ijbiomac.2024.134362.
Full text not available from this repository.Abstract
Healing diabetic ulcers with chronic inflammation is a major challenge for researchers and professionals, necessitating new strategies. To rapidly treat diabetic wounds in rat models, we have fabricated a composite scaffold composed of alginate (Alg) and silk fibroin (SF) as a wound dressing that is laden with molecules of lithium chloride (LC). The physicochemical, bioactivity, and biocompatibility properties of Alg-SF-LC scaffolds were investigated in contrast to those of Alg, SF, and Alg-SF ones. Afterward, full-thickness wounds were ulcerated in diabetic rats in order to evaluate the capacity of LC-laden scaffolds to regenerate skin. The characterization findings demonstrated that the composite scaffolds possessed favorable antibacterial properties, cell compatibility, high swelling, controlled degradability, and good uniformity in the interconnected pore microstructure. Additionally, in terms of wound contraction, re-epithelialization, and angiogenesis improvement, LCladen scaffolds revealed better performance in diabetic wound healing than the other groups. This research indicates that utilizing lithium chloride molecules loaded in biological materials supports the best diabetic ulcer regeneration in vivo, and produces a skin replacement with a cellular structure comparable to native skin.
| Item Type: | Article |
|---|---|
| Funders: | Golestan University of Medical Sciences (IR.IUMS.REC.1400.1178) |
| Uncontrolled Keywords: | Lithium chloride; Silk fibroin; Alginate; Diabetic wound; Angiogenesis |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Orthopaedic Surgery Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 10 Apr 2025 04:31 |
| Last Modified: | 10 Apr 2025 04:31 |
| URI: | http://eprints.um.edu.my/id/eprint/46684 |
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