Rahman, Nur Adilah Abdul and Fuaad, Abdullah Al-Hadi Ahmad and Azami, Nor Azila Muhammad and Amin, Mohd Cairul Iqbal Mohd and Azmi, Fazren (2024) Next-generation Dengue Vaccines: Leveraging Peptide-Based Immunogens and Advanced Nanoparticles as Delivery Platforms. Journal of Pharmaceutical Sciences, 113 (8). pp. 2044-2054. ISSN 0022-3549, DOI https://doi.org/10.1016/j.xphs.2024.05.010.
Full text not available from this repository.Abstract
Dengue, caused by the dengue virus (DENV), is a prevalent arthropod-borne disease in humans and poses a significant burden on public health. Severe cases of dengue can be life-threatening. Although a licensed dengue vaccine is available, its efficacy varies across different virus serotypes and may exacerbate the disease in some seronegative recipients. Developing a safe and effective vaccine against all DENV serotypes remains challenging and requires continued research. Conventional approaches in dengue vaccine development, using live or attenuated microorganisms or parts of them often contain unnecessary epitopes, risking allergenic or autoimmune reactions. To address these challenges, innovative strategies such as peptide vaccines have been explored. Peptide vaccines offer a safer alternative by inducing specific immune responses with minimal immunogenic fragments. Chemical modification strategies of peptides have revolutionized their design, allowing for the incorporation of multi-epitope presentation, self-adjuvanting features, and self- assembling properties. These modifications enhance the antigenicity of the peptides, leading to improved vaccine efficacy. This review outlines advancements in peptide-based dengue vaccine development, leveraging nanoparticles as antigen-displaying platforms. Additionally, key immunological considerations for enhancing efficacy and safety against DENV infection have been addressed, providing insight into the next- generation of dengue vaccine development leveraging on peptide-nanoparticle technology. (c) 2024 American Pharmacists Association. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Kebangsaan Malaysia (UKM) Research University Grant (GUP-2021-004) |
| Uncontrolled Keywords: | Vaccine(s); Nanoparticle(s); Peptide epitope(s); Dengue |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Apr 2025 03:36 |
| Last Modified: | 14 Apr 2025 03:36 |
| URI: | http://eprints.um.edu.my/id/eprint/46611 |
Actions (login required)
 |
View Item |
