Hapis, Nur Aina Najiha Amin and Rashid, Nurshamimi Nor and Choo, Yeun-Mun (2024) Harnessing Natural Resources for Advancements in Dengue Virus Treatment. Current Topics in Medicinal Chemistry, 24 (27). pp. 2337-2350. ISSN 1568-0266, DOI https://doi.org/10.2174/0115680266312717240821062535.
Full text not available from this repository.Abstract
Dengue fever, caused by the Dengue virus (DENV) and transmitted by Aedes aegypti mosquitoes, has become endemic in over 100 countries. Despite considerable research, there is a lack of specific drugs for clinical use against dengue. Hence, further exploration to identify anti-dengue compounds is essential. In recent years, natural products have gained attention for their antiviral properties. Plant-based medicines are particularly appealing due to their safety and low toxicity. This review summarizes natural compounds with potential antiviral activity against DENV, highlighting their mechanisms of action. Various compounds, from traditional herbal remedies to novel plant isolates, show promise against dengue, targeting crucial viral proteins like the envelope protein, proteases, and RNA polymerase. Exploring natural sources of antiviral agents against dengue is crucial. These compounds offer hope for effective treatments and mitigating dengue's global impact.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education (MOHE), Malaysia (IF070-2020), Science and Technology Research Partnership for Sustainable Development (SA-TREPS) programme, Japan Agency for Medical Research and Development (AMED), Japan International Cooperation Agency (JICA) |
| Uncontrolled Keywords: | Dengue; DENV; natural products; E protein; NS1 protein; NS2B-NS3 protease; NS5 protein |
| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Department of Molecular Medicine Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 09 Apr 2025 06:30 |
| Last Modified: | 09 Apr 2025 06:30 |
| URI: | http://eprints.um.edu.my/id/eprint/46608 |
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