Application of 3D-printed bioinks in chronic wound healing: A scoping review

Abuhamad, Asmaa Y. and Masri, Syafira and Fadilah, Nur Izzah Md and Alamassi, Mohammed Numan and Maarof, Manira and Fauzi, Mh Busra (2024) Application of 3D-printed bioinks in chronic wound healing: A scoping review. Polymers, 16 (17). ISSN 2073-4360, DOI https://doi.org/10.3390/polym16172456.

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Abstract

Chronic wounds, such as diabetic foot ulcers, pressure ulcers, and venous ulcers, pose significant clinical challenges and burden healthcare systems worldwide. The advent of 3D bioprinting technologies offers innovative solutions for enhancing chronic wound care. This scoping review evaluates the applications, methodologies, and effectiveness of 3D-printed bioinks in chronic wound healing, focusing on bioinks incorporating living cells to facilitate wound closure and tissue regeneration. Relevant studies were identified through comprehensive searches in databases, including PubMed, Scopus, and Web of Science databases, following strict inclusion criteria. These studies employ various 3D bioprinting techniques, predominantly extrusion-based, to create bioinks from natural or synthetic polymers. These bioinks are designed to support cell viability, promote angiogenesis, and provide structural integrity to the wound site. Despite these promising results, further research is necessary to optimize bioink formulations and printing parameters for clinical application. Overall, 3D-printed bioinks offer a transformative approach to chronic wound care, providing tailored and efficient solutions. Continued development and refinement of these technologies hold significant promise for improving chronic wound management and patient outcomes.

Item Type: Article
Funders: Universiti Kebangsaan Malaysia [Grant No: DIP-2023-018], Universiti Kebangsaan Malaysia under Dana Impak Perdana 2.0 (DIP 2.0)
Uncontrolled Keywords: Chronic wound healing; 3D printing; Bioink; Cell-laden; Regenerative medicine
Subjects: R Medicine
R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 13 Oct 2025 02:27
Last Modified: 13 Oct 2025 02:27
URI: http://eprints.um.edu.my/id/eprint/46534

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