Carbon nanomaterials as electrochemical sensors for theophylline: A review

Sutanto, Laurencia Gabrielle and Sabilla, Syarifa and Wardhana, Brasstira Yuva and Ramadani, Anggi and Sari, Anis Puspita and Anjani, Qonita Kurnia and Basirun, Wan Jeffrey and Amrillah, Tahta and Amalina, Ilma and Jiwanti, Prastika Krisma (2024) Carbon nanomaterials as electrochemical sensors for theophylline: A review. RSC Advances, 14 (39). pp. 28927-28942. ISSN 2046-2069, DOI https://doi.org/10.1039/d4ra03585b.

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Abstract

Theophylline (TP) is a methylxanthine derivative, which serves as a valuable compound in treating respiratory disorders and acts as a bronchodilator agent. However, TP has a limited therapeutic range (20-100 mu mol L-1), demanding precise monitoring to prevent potential drug toxicity even with slight level fluctuations during treatment. Thus, to overcome this limitation, electrochemical methods have been extensively used due to their efficacy in achieving sensitivity, selectivity, and accuracy. In the context of electrochemical sensors, nanocarbon-based materials have gained widespread recognition for their extensive applications. Therefore, this review aims to explore the latest advancements in carbon-based electrodes particularly used for the precise determination of TP through electrochemical methods. The results are expected to provide insights into the profound significance of the methods in enhancing the accuracy and sensitivity for the detection of TP. Recent progress in the utilization of nanocarbon-based materials, such as graphene, nanodiamond, and CNTs, is discussed regarding their enhanced performance in electrochemical sensors for theophylline.

Item Type: Article
Funders: Universitas Airlangga [Grant No: 191/UN3 LPPM/PT.01.03/2024], Universitas Airlangga by International Report Consortium
Uncontrolled Keywords: Nanocomposite; Electroanalytical application; Gold nanoparticle
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 13 Oct 2025 04:03
Last Modified: 13 Oct 2025 04:03
URI: http://eprints.um.edu.my/id/eprint/46525

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