Sim, Nicholas Choo Wee and Al-Maleki, Anis Rageh and Sulaiman, Eshamsul and Mohamad-Hassan, Norul Husna and Safii, Syarida Hasnur (2024) Clinical outcomes and supragingival microbiota analysis around dental implants and teeth in patients with a history of periodontitis: A preliminary study of 6 months follow-up. Clinical Oral Investigations, 28 (10). ISSN 1432-6981, DOI https://doi.org/10.1007/s00784-024-05922-w.
Full text not available from this repository.Abstract
Objectives To investigate the supragingival microbiome surrounding dental implants and neighbouring tooth in periodontitis history and periodontally healthy patients. Methods Subjects with a history of periodontitis (test) and periodontally healthy subjects (control) received one of two types of dental implants with different surface characteristics: sandblasted acid-etched (SLA) or precision dimension laser-treated (PDL). Periodontal clinical measurements were collected at baseline (V1), 3 months after implant placement (V4), at zirconia crown placement (V6) and 3 months after zirconia crown placement (V8). Supragingival bacterial microbiota was studied using Illumina MiSeq sequencing. Results Supragingival microbial community on SLA implants in test group significantly differed to control group at V8 (p < 0.05). A longitudinal shift displaying microbial dysbiosis occurred on SLA implants (p < 0.05) and adjacent teeth (p < 0.05) among test patients from V6 to V8. On PDL implants and the adjacent tooth, no significant difference between test and control groups from V6 to V8 (p > 0.05). Co-occurrence network in test group of SLA implants and the adjacent tooth at V8 showed increased disease-associated bacteria and reduced health-associated bacteria. Health-associated bacteria were dominant in control group of SLA implants at V8. Conclusion The surface characteristics and prosthetic components of dental implants may be important risk factors in patients with a history of periodontitis. Clinical relevance Dysbiosis of supragingival microbiome may predispose dental implants to peri-implant diseases. Thus, a strict supportive periodontal care plan is imperative to prevent early onset of biological complications.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia, Department of Restorative Dentistry, Universiti Malaya |
| Uncontrolled Keywords: | History of periodontitis; Implant; Adjacent tooth; Supragingival microbiota; 16s rRNA gene sequencing |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Department of Restorative Dentistry Faculty of Medicine > Medical Microbiology Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 22 Oct 2025 03:08 |
| Last Modified: | 22 Oct 2025 03:08 |
| URI: | http://eprints.um.edu.my/id/eprint/46477 |
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