Fadzuli, Nurul Izzati Ahmad and Lim, Siong Meng and Neoh, Chin Fen and Majeed, Abu Bakar Abdul and Tan, Maw Pin and Khor, Hui Min and Tan, Ai Huey and Ramasamy, Kalavathy (2024) Faecal intestinal permeability and intestinal inflammatory markers in older adults with age-related disorders: A systematic review and meta-analysis. Ageing Research Reviews, 101. ISSN 1568-1637, DOI https://doi.org/10.1016/j.arr.2024.102506.
Full text not available from this repository.Abstract
This systematic review and meta-analysis appraised previous findings to uncover potential faecal intestinal permeability and intestinal inflammatory markers in older adults. A comprehensive literature search led to the identification of ten eligible studies with findings of potential faecal intestinal permeability (zonulin and alpha-1-antitrypsin) and intestinal inflammatory markers calprotectin, lactoferrin and neutrophil gelatinase-associated lipocalin (NGAL)]. Most of the cases (n > 2) Parkinson's disease (PD) and Alzheimer's disease (AD)] exhibited higher faecal alpha-1-antitrypsin, zonulin and calprotectin levels. The present meta-analysis confirmed significantly higher faecal alpha-1-antitrypsin in older persons with PD compared to non-PD MD = 22.92 mg/dL; 95 % CI = 14.02-31.81, p < 0.00001; I-2 = 0 % (p = 0.73)]. There was, however, no significant difference in faecal zonulin between PD and non-PD individuals MD = 26.88 ng/mL; 95 % CI = -29.26-83.01, p = 0.35; I-2 = 94 % (p < 0.0001)]. Meanwhile, faecal calprotectin was higher in older adults with GI symptoms, multiple system atrophy (MSA) or PD than the healthy controls MD = 9.51 mu g/g; 95 % CI = 0.07-18.95, p = 0.05; I-2 = 84 % (p < 0.00001)]. Altogether, faecal calprotectin appears to be a potential intestinal inflammatory marker whereas previous findings on faecal alpha-1-antitrypsin as an intestinal permeability marker remain limited and require further validation.
| Item Type: | Article |
|---|---|
| Funders: | Long-Term Research Grant Scheme, Ministry of Higher Education, Malaysia [Grant no. LRGS/1/2019/UM/01/1/3] |
| Uncontrolled Keywords: | Older adults; Intestinal permeability; Intestinal inflammation; Faecal markers; Calprotectin; Alpha-1-antitrypsin |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 Oct 2025 03:16 |
| Last Modified: | 26 Oct 2025 03:16 |
| URI: | http://eprints.um.edu.my/id/eprint/46445 |
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