Marlina, Anita and Misran, Misni and Ndruru, Sun Theo Constan Lotebulo and Mat Saad, Hazwani and Sim, Kae Shin (2024) Development and characterization of tannic acid-modified PVA-κCarrageenan gel for sustained release of lidocaine. ChemistrySelect, 9 (37). ISSN 2365-6549, DOI https://doi.org/10.1002/slct.202400387.
Full text not available from this repository.Abstract
PVA-kappa carrageenan (kappa Car) gel is widely used in the pharmaceutical field for transdermal drug delivery, enhancing drug stability and bioavailability. This study aims to modify PVA-kappa Car gel by introducing tannic acid. Lidocaine was used as a model drug for incorporation into the novel gel. The PVA-kappa Car matrix was mixed with tannic acid prior to freeze- thaw cycle to create a gel composite. The physicochemical features of this gel were evaluated using FTIR, XRD, thermal analysis, and SEM. The presence of tannic acid has reduced the thermal stability of PVA-kappa Car from 84 to around 70 degrees C. The gel content of tannic acid-modified PVA-kappa Car was 34.6% (A) and 52.1% (B). The addition of tannic acid substantially increased gel viscosity. Cytotoxicity analysis showed that tannic acid-modified PVA-kappa Car gel did not affect the viability of HCT colon cancer cells. The encapsulation efficiency of lidocaine in tannic acid-modified PVA-kappa Car was 13 +/- 0.2% (A) and 12 +/- 0.5% (B), while the drug loading was 0.96 +/- 0.01 (A) and 0.91 +/- 0.02 (B). In vitro release of lidocaine from the modified PVA-kappa Car exhibited a sustained release mechanism in phosphate-buffered saline solution. These findings indicate that the gel possesses advantageous characteristics as a drug carrier.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Gel; Kappa Carrageenan; PVA; Sustained release; Tannic acid |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Centre for Foundation Studies in Science Faculty of Science > Institute of Biological Sciences Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 27 Oct 2025 03:53 |
| Last Modified: | 27 Oct 2025 03:53 |
| URI: | http://eprints.um.edu.my/id/eprint/46421 |
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