Khazali, Ahmad Suhail and Hadrawi, Waqiyuddin Hilmi and Ibrahim, Fatimah and Othman, Shatrah and Rashid, Nurshamimi Nor (2024) Thrombocytopenia in dengue infection: Mechanisms and a potential application. Expert Reviews in Molecular Medicine, 26. ISSN 1462-3994, DOI https://doi.org/10.1017/erm.2024.18.
Full text not available from this repository.Abstract
Thrombocytopenia is a common symptom and one of the warning signs of dengue virus (DENV) infection. Platelet depletion is critical as it may lead to other severe dengue symptoms. Understanding the molecular events of this condition during dengue infection is challenging because of the multifaceted factors involved in DENV infection and the dynamics of the disease progression. Platelet levels depend on the balance between platelet production and platelet consumption or clearance. Megakaryopoiesis and thrombopoiesis, two interdependent processes in platelet production, are hampered during dengue infection. Conversely, platelet elimination via platelet activation, apoptosis and clearance processes are elevated. Together, these anomalies contribute to thrombocytopenia in dengue patients. Targeting the molecular events of dengue-mediated thrombocytopenia shows great potential but still requires further investigation. Nonetheless, the application of new knowledge in this field, such as immature platelet fraction analysis, may facilitate physicians in monitoring the progression of the disease.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Immature platelet fraction; Megakaryopoiesis; Platelet; Thrombocytopenia; Thrombopoiesis |
| Subjects: | R Medicine |
| Divisions: | Faculty of Engineering > Department of Biomedical Engineering Faculty of Medicine > Department of Molecular Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 29 Oct 2025 01:33 |
| Last Modified: | 29 Oct 2025 01:33 |
| URI: | http://eprints.um.edu.my/id/eprint/46364 |
Actions (login required)
 |
View Item |
