Mousavi, Seyyed Mojtaba and Hashemi, Seyyed Alireza and Bahrani, Sonia and Sadrmousavi-Dizaj, Asma and Arjmand, Omid and Omidifar, Navid and Lai, Chin Wei and Chiang, Wei-Hung and Gholami, Ahmad (2022) Bioinorganic synthesis of sodium polytungstate/polyoxometalate in microbial kombucha media for precise detection of doxorubicin. BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2022. ISSN 1687-479X, DOI https://doi.org/10.1155/2022/2265108.
Full text not available from this repository.Abstract
In this study, we have developed a new platform of polyoxometalate as a biocompatible and electrosensitive polymeric biosensor for the accurate detection of doxorubicin. For this purpose, we used a green synthesis approach using tartaric acid, glutamic acid, and kombucha solvent. Thanks to its bioinorganic components, the biogenic approach can chemically modify and improve the performance of the biosensor, which was experimentally confirmed. Our results showed excellent sensitivity (175.72 mu A center dot mu M-1 center dot cm(-2)), low detection limit (DL, 8.12 nM), and low quantification limit (QL, 0.056 mu M) when the newly developed biosensor was used. The results also show that the biosynthesized biosensor has improved performance in detecting DOX in the biological fluid with an accuracy of more than 99% depending on the components used, which underlines the high efficiency of the biosensor produced. Considering the body's physiological condition, the biosensor fabricated as a biocompatible component can show high efficiency. Therefore, its applicability for clinical use still needs to be studied in detail.
| Item Type: | Article |
|---|---|
| Funders: | Shiraz University of Medical Sciences, Shiraz, Iran - Shiraz University of Medical Sciences, Shiraz, Iran [98-01-36-19698] |
| Uncontrolled Keywords: | GRAPHENE OXIDE; IN-VITRO; SENSOR; POLYOXOMETALATE; HYDROCHLORIDE; NANOPARTICLES; BIOSENSORS; ACID |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Nanotechnology & Catalysis Research Centre Institute of Advanced Studies |
| Depositing User: | Ms Koh Ai Peng |
| Date Deposited: | 24 Jul 2024 07:02 |
| Last Modified: | 24 Jul 2024 07:02 |
| URI: | http://eprints.um.edu.my/id/eprint/46265 |
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