Chew, C.S.N. and Cherry, C.L. and Imran, D. and Yunihastuti, E. and Kamarulzaman, A. and Varna, S. and Ismail, R. and Phipps, M. and Aghafar, Z. and Gut, I. and Price, P. (2011) Tumour necrosis factor haplotypes associated with sensory neuropathy in Asian and Caucasian human immunodeficiency virus patients. Tissue Antigens, 77 (2). pp. 126-130. ISSN 0001-2815,
Full text not available from this repository.Abstract
In human immunodeficiency virus (HIV) patients, neuropathy is a common adverse side effect to some antiretroviral treatments, particularly stavudine. As stavudine is cheap, it is widely used in Asia and Africa. We showed that increasing age and height moderately predict the development of neuropathy. This was improved by the inclusion of tumour necrosis factor (TNF)-1031 (rs1799964). To investigate this association, Malay (n = 64), Chinese (n = 74) and Caucasian patients (n = 37) exposed to stavudine were screened for neuropathy. DNA samples were genotyped for polymorphisms in the central major histocompatibility complex (MHC) near TNF, and haplotypes were derived. The haplotype group FVa6,7,8 (incorporating TNF-1031) was found to be associated with neuropathy in Chinese patients in bivariate analyses (P = 0.03), and in Malays and Chinese in a multivariate analysis correcting for age and height (P = 0.02, P = 0.03, respectively). This trend was also confirmed in Caucasians.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Chew, C. S. N. Cherry, C. L. Imran, D. Yunihastuti, E. Kamarulzaman, A. Varna, S. Ismail, R. Phipps, M. Aghafar, Z. Gut, I. Price, P. |
| Uncontrolled Keywords: | TNF haplotype;immunogenetics;neuropathy;HIV;NRTI;inflammation |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms azrahani halim |
| Date Deposited: | 04 Feb 2013 01:56 |
| Last Modified: | 04 Feb 2013 01:56 |
| URI: | http://eprints.um.edu.my/id/eprint/4626 |
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