Keusch, Gerald T. and Amuasi, John H. and Anderson, Danielle E. and Daszak, Peter and Eckerle, Isabella and Field, Hume and Koopmans, Marion and Lam, Sai Kit and Das Neves, Carlos G. and Peiris, Malik and Perlman, Stanley and Wacharapluesadee, Supaporn and Yadana, Su and Saif, Linda (2022) Pandemic origins and a One Health approach to preparedness and prevention: Solutions based on SARS-CoV-2 and other RNA viruses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119 (42). ISSN 1091-6490, DOI https://doi.org/10.1073/pnas.2202871119.
Full text not available from this repository.Abstract
COVID-19 is the latest zoonotic RNA virus epidemic of con-cern. Learning how it began and spread will help to deter-mine how to reduce the risk of future events. We review major RNA virus outbreaks since 1967 to identify common features and opportunities to prevent emergence, including ancestral viral origins in birds, bats, and other mammals; animal reservoirs and intermediate hosts; and pathways for zoonotic spillover and community spread, leading to local, regional, or international outbreaks. The increasing scientific evidence concerning the origins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is most consistent with a zoonotic origin and a spillover pathway from wildlife to people via wildlife farming and the wildlife trade. We apply what we know about these outbreaks to identify relevant, feasible, and implementable interventions. We identify three primary targets for pandemic prevention and preparedness: first, smart surveillance coupled with epide-miological risk assessment across wildlife-livestock-human (One Health) spillover interfaces; second, research to enhance pandemic preparedness and expedite develop-ment of vaccines and therapeutics; and third, strategies to reduce underlying drivers of spillover risk and spread and reduce the influence of misinformation. For all three, contin-ued efforts to improve and integrate biosafety and biosecur-ity with the implementation of a One Health approach are essential. We discuss new models to address the challenges of creating an inclusive and effective governance structure, with the necessary stable funding for cross-disciplinary col-laborative research. Finally, we offer recommendations for feasible actions to close the knowledge gaps across the One Health continuum and improve preparedness and response in the future.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | pandemic preparedness; COVID-19 origins and spread; Drivers of emerging infectious diseases; spillover and spillback I One Health solutions |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Universiti Malaya |
| Depositing User: | Ms Koh Ai Peng |
| Date Deposited: | 25 Jul 2024 06:34 |
| Last Modified: | 25 Jul 2024 06:34 |
| URI: | http://eprints.um.edu.my/id/eprint/46232 |
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