Tan, D.B.A. and Yong, Y.K. and Lim, A. and Tan, H.Y. and Kamarulzaman, A. and French, M. and Price, P. (2011) Robust interferon-alpha and IL-12 responses by dendritic cells are related to efficient CD4(+) T-cell recovery in HIV patients on ART. Clinical Immunology, 139 (2). pp. 115-121. ISSN 1521-6616,
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Abstract
Amongst HIV patients with successful virological responses to antiretroviral therapy (ART), poor CD4(+) T-cell recovery is associated with low nadir CD4(+) T-cell counts and persistent immune activation. These factors might be influenced by dendritic cell (DC) function. Interferon-alpha-producing plasmacytoid DC and IL-12-producing myeloid DC were quantified by flow cytometry after stimulation with agonists to TLR7/8 (CL075) or TLR9 (CpG-ODN). These were compared between patients who achieved CD4(+) T-cell counts above or below 200 cells/mu L after 6 months on ART (High vs. Low groups). High Group patients had more DC producing interferon-alpha or IL-12 at Weeks 6 and 12 on ART than Low Group patients. The frequencies of cytokine-producing DC at Week 12 were directly correlated with CD4(+) T-cell counts at baseline and at Week 12. Patients with good recovery of CD4(+) T-cells had robust TLR-mediated interferon-alpha responses by plasmacytoid DC and IL-12 responses by myeloid DC during early ART (1-3 months). (C) 2011 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Tan, Dino Bee Aik Yong, Yean Kong Lim, Andrew Tan, Hong Yien Kamarulzaman, Adeeba French, Martyn Price, Patricia |
| Uncontrolled Keywords: | Antiretroviral therapy; HIV; Interferon-α; IL-12; Dendritic cells; Toll-like receptors |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms azrahani halim |
| Date Deposited: | 04 Feb 2013 03:46 |
| Last Modified: | 04 Feb 2013 03:46 |
| URI: | http://eprints.um.edu.my/id/eprint/4616 |
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