Sargsian, Shushan and Chen, Ze and Lee, Soo Ching and Robertson, Amicha and Thur, Rafaela Saes and Sproch, Julia and Devlin, Joseph C. and Tee, Mian Zi and Er, Yi Xian and Copin, Richard and Heguy, Adriana and Pironti, Alejandro and Torres, Victor J. and Ruggles, Kelly V. and Lim, Yvonne A. L. and Bethony, Jeffrey and Loke, P'ng and Cadwell, Ken (2022) Clostridia isolated from helminth-colonized humans promote the life cycle of Trichuris species. CELL REPORTS, 41 (9). ISSN 2211-1247, DOI https://doi.org/10.1016/j.celrep.2022.111725.
Full text not available from this repository.Abstract
Soil-transmitted intestinal worms known as helminths colonize over 1.5 billion people worldwide. Although helminth colonization has been associated with altered composition of the gut microbiota, such as increases in Clostridia, individual species have not been isolated and characterized. Here, we isolate and sequence the genome of 13 Clostridia from the Orang Asli, an indigenous population in Malaysia with a high prevalence of helminth infections. Metagenomic analysis of 650 fecal samples from urban and rural Malaysians confirm the prevalence of species corresponding to these isolates and reveal a specific association between Peptostrep-tococcaceae family members and helminth colonization. Remarkably, Peptostreptococcaceae isolated from the Orang Asli display superior capacity to promote the life cycle of whipworm species, including hatching of eggs from Trichuris muris and Trichuris trichiura. These findings support a model in which helminths select for gut colonization of microbes that support their life cycle.
| Item Type: | Article |
|---|---|
| Funders: | United States Department of Health & Human Services National Institutes of Health (NIH) - USA, Howard Hughes Medical Institute, Crohn's & Colitis Foundation of America, Kenneth Rainin Foundation, Judith & Stewart Colton Center of Autoimmunity, NYU Langone Health Antimicrobial-Resistant Pathogens Program, PacBio Local SMRT Grant, Intramural Research Program of NIAID |
| Uncontrolled Keywords: | REGULATORY T-CELLS; GUT MICROBIOTA; CONSEQUENCES; INFLAMMATION; INFECTIONS; INDUCTION; INTESTINE; SEQUENCE; IMMUNITY; STRAINS |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Medicine > Biomedical Science Department Faculty of Medicine > Parasitology Deparment |
| Depositing User: | Ms Koh Ai Peng |
| Date Deposited: | 29 Oct 2024 06:37 |
| Last Modified: | 29 Oct 2024 06:37 |
| URI: | http://eprints.um.edu.my/id/eprint/46150 |
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