Reconstructing the epidemic history of HIV-1 circulating recombinant forms CRF07BC and CRF08BC in East Asia: the relevance of genetic diversity and phylodynamics for vaccine strategies

Takebe, Y. and Liao, H.N. and Hase, S. and Uenishi, R. and Li, Y.E. and Li, X.J. and Han, X.X. and Shang, H. and Kamarulzaman, A. and Yamamoto, N. and Pybus, O.G. and Tee, K.K. (2010) Reconstructing the epidemic history of HIV-1 circulating recombinant forms CRF07BC and CRF08BC in East Asia: the relevance of genetic diversity and phylodynamics for vaccine strategies. Vaccine, 28. B39-B44. ISSN 0264-410X,

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Abstract

HIV-1 CRF07BC and CRF08BC are closely related circulating recombinant forms (CRFs) with serious public health consequences in China. The temporal and spatial dynamics of these CRI's were determined by estimating their times of divergence, using phylogenetic and Bayesian coalescent methods. Studies of the timelines of CRF07BC and CRF08BC trace the expansion of these strains back their origins to Yunnan province. The present study highlights the relevance of incorporating evolutionary and molecular epidemiological analyses into an in-depth understanding of the genesis of HIV epidemic, providing information for determining regional and global public health policies, including future vaccine strategies. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Funders: UNSPECIFIED
Additional Information: Takebe, Yutaka Liao, Huanan Hase, Saiki Uenishi, Rie Li, Yue Li, Xiao-Jie Han, Xiaoxu Shang, Hong Kamarulzaman, Adeeba Yamamoto, Naoki Pybus, Oliver G. Tee, Kok Keng 2
Uncontrolled Keywords: HIV-1; Circulating recombinant form (CRF); Phylodynamics; BEAST; Time of the most recent common ancestor (tMRCA); East Asia; Vaccine strategies
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms azrahani halim
Date Deposited: 04 Feb 2013 03:39
Last Modified: 04 Feb 2013 03:39
URI: http://eprints.um.edu.my/id/eprint/4613

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