Koo, Zhao Peng and Singh, Mansharan Kaur Chainchel and Mohamad Noor, Mohamad Helmee and Omar, Norhayati and Siew, Sheue Feng (2024) Fatal anterior mediastinal mass in a pregnant lady. Forensic Science Medicine and Pathology, 20 (1). pp. 226-232. ISSN 1547769X, DOI https://doi.org/10.1007/s12024-023-00669-4.
Full text not available from this repository.Abstract
We report a fatal case of a 26-year-old nulliparous woman who presented with an anterior mediastinal mass in her late pregnancy. She had complained of a progressively increasing neck swelling and occasional dry cough in the early second trimester, which was associated with worsening dyspnoea, reduced effort tolerance and orthopnoea. Ultrasound of the neck showed an enlarged lymph node, and chest X-ray revealed mediastinal widening. At 35 weeks' gestation, the patient was referred to a tertiary centre for a computed tomography (CT) scan of the neck and thorax under elective intubation via awake fibreoptic nasal intubation as she was unable to lie flat. However, she developed sudden bradycardia, hypotension and desaturation soon after being positioned supine, which required resuscitation. She succumbed after 3 days in the intensive care unit. An autopsy revealed a large anterior mediastinal mass extending to the right supraclavicular region, displacing the heart and lungs, encircling the superior vena cava and right internal jugular vein with tumour thrombus extending into the right atrium. Histopathology examination of the mediastinal mass confirmed the diagnosis of a primary mediastinal large B-cell lymphoma. This report emphasizes the severe and fatal outcome resulting from the delay and misinterpretation of symptoms related to a mediastinal mass.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Anterior mediastinal mass; Non-Hodgkin's lymphoma (NHL); Primary mediastinal large B-cell lymphoma (PMBCL); Pregnancy |
| Subjects: | R Medicine > RG Gynecology and obstetrics R Medicine > RG Gynecology and obstetrics > Obstetrics R Medicine > RG Gynecology and obstetrics > Obstetrics > Pregnanc |
| Divisions: | Universiti Malaya Medical Centre (UMMC) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Aug 2024 03:52 |
| Last Modified: | 20 Aug 2024 03:52 |
| URI: | http://eprints.um.edu.my/id/eprint/46036 |
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