Rosenthal, Victor Daniel and Jin, Zhilin and Yin, Ruijie and Sahu, Suneeta and Rajhans, Prasad and Kharbanda, Mohit and Nair, Pravin K. and Mishra, Shakti Bedanta and Chawla, Rajesh and Arjun, Rajalakshmi and Sandhu, Kavita and Rodrigues, Camilla and Dongol, Reshma and Myatra, Sheila Nainan and Mohd-Basri, Mat Nor and Chian-Wern, Tai and Bhakta, Arpita and Bat-Erdene, Ider and Acharya, Subhash P. and Alvarez, Gustavo Andres and Moreno, Lina Alejandra Aguilar and Gomez, Katherine and da Jimenez-Alvarez, Luisa Fernanda and Henao-Rodas, Claudia Milena and Valderrama-Beltran, Sandra Liliana and Zuniga-Chavarria, Maria Adelia and Aguirre-Avalos, Guadalupe and Hernandez-Chena, Blanca Estela and Sassoe-Gonzalez, Alejandro and Aleman-Bocanegra, Mary Cruz and Villegas-Mota, Maria Isabel and De Moros, Daisy Aguilar and Castaneda-Sabogal, Alex and Carreazo, Nilton Yhuri and Alkhawaja, Safaa and Agha, Hala Mounir and El-Kholy, Amani and Abdellatif-Daboor, Mohammad and Dursun, Oguz and Okulu, Emel and Havan, Merve and Yildizdas, Dincer and Deniz, Suna Secil Ozturk and Guclu, Ertugrul and Hlinkova, Sona and Ikram, Aamer and Tao, Lili and Omar, Abeer Aly and Elahi, Naheed and Memish, Ziad A. and Petrov, Michael M. and Raka, Lul and Janc, Jaroslaw and Horhat-Florin, George and Medeiros, Eduardo Alexandrino and Salgado, Estuardo and Duenas, Lourdes and Coloma, Monica and Perez, Valentina and Brown, Eric Christopher (2024) Assessing the impact of a multidimensional approach and an 8-component bundle in reducing incidences of ventilator-associated pneumonia across 35 countries in Latin America, Asia, the Middle East, and Eastern Europe. Journal of Critical Care, 80. p. 154500. ISSN 0883-9441, DOI https://doi.org/10.1016/j.jcrc.2023.154500.
Full text not available from this repository.Abstract
Background: Ventilator associated pneumonia (VAP) occurring in the intensive care unit (ICU) are common, costly, and potentially lethal. Methods: We implemented a multidimensional approach and an 8-component bundle in 374 ICUs across 35 low and middle-income countries (LMICs) from Latin-America, Asia, Eastern-Europe, and the Middle-East, to reduce VAP rates in ICUs. The VAP rate per 1000 mechanical ventilator (MV)-days was measured at baseline and during intervention at the 2nd month, 3rd month, 4-15 month, 16-27 month, and 28-39 month periods. Results: 174,987 patients, during 1,201,592 patient-days, used 463,592 MV-days. VAP per 1000 MV-days rates decreased from 28.46 at baseline to 17.58 at the 2nd month (RR = 0.61; 95% CI = 0.58-0.65; P < 0.001); 13.97 at the 3rd month (RR = 0.49; 95% CI = 0.46-0.52; P < 0.001); 14.44 at the 4-15 month (RR = 0.51; 95% CI = 0.48-0.53; P < 0.001); 11.40 at the 16-27 month (RR = 0.41; 95% CI = 0.38-0.42; P < 0.001), and to 9.68 at the 28-39 month (RR = 0.34; 95% CI = 0.32-0.36; P < 0.001). The multilevel Poisson regression model showed a continuous significant decrease in incidence rate ratios, reaching 0.39 (p < 0.0001) during the 28th to 39th months after implementation of the intervention. Conclusions: This intervention resulted in a significant VAP rate reduction by 66% that was maintained throughout the 39-month period.
| Item Type: | Article |
|---|---|
| Funders: | INICC foundation |
| Uncontrolled Keywords: | Hospital infection; Nosocomial infection; Healthcare-associated infection; Device-associated infection; Ventilator-associated pneumonia; Developing countries; Limited resources countries; Low-income countries; Network |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Universiti Malaya Medical Centre (UMMC) |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Nov 2024 07:12 |
| Last Modified: | 14 Nov 2024 07:12 |
| URI: | http://eprints.um.edu.my/id/eprint/45941 |
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