Li, Yue and Tee, Kok Keng and Liao, Huanan and Hase, Saiki and Uenishi, Rie and Li, Xiao-Jie and Tsuchiura, Takayo and Yang, Rongge and Govindasamy, Sumathi and Yong, Yean Kong and Tan, Hong Yien and Pybus, Oliver G. and Kamarulzaman, Adeeba and Takebe, Yutaka (2010) Identification of a Novel Second-Generation Circulating Recombinant Form (CRF48_01B) in Malaysia: A Descendant of the Previously Identified CRF33_01B. Journal of Acquired Immune Deficiency Syndromes, 54 (2). pp. 129-136. ISSN 1525-4135, DOI https://doi.org/10.1097/QAI.0b013e3181d82ce5.
Full text not available from this repository.Abstract
A molecular epidemiological investigation conducted among injecting drug users in eastern Peninsular Malaysia in 2007 identified a cluster of sequences (n = 3) located outside any known HIV-1 genotype. Analyses of near full-length nucleotide sequences of these strains from individuals with no recognizable linkage revealed that they have an identical subtype structure comprised of CRF01_AE and subtype B', distinct from any known circulating recombinant forms (CRFs). This novel CRF, designated CRF48_01B, is closely related to CRF33_01B, previously identified in Kuala Lumpur. Phylogenetic analysis of multiple CRF48_01B genome regions showed that CRF48_01B forms a monophyletic cluster within CRF33_01B, suggesting that this new recombinant is very likely a descendant of CRF33_01B. CRF48_01B thus represents one of the first examples of a "second-generation" CRF, generated by additional crossover with pre-existing CRFs. Corroborating these results, Bayesian molecular clock analyses indicated that CRF48_01B emerged in ~2001, approximately ~8 years after the emergence of CRF33_01B.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Li, Yue Tee, Kok Keng Liao, Huanan Hase, Saiki Uenishi, Rie Li, Xiao-Jie Tsuchiura, Takayo Yang, Rongge Govindasamy, Sumathi Yong, Yean Kong Tan, Hong Yien Pybus, Oliver G. Kamarulzaman, Adeeba Takebe, Yutaka |
| Uncontrolled Keywords: | Asia; Bayesian coalescent analysis; circulating recombinant form; CRF33_01B; CRF48_01B; injection drug user; Malaysia; phylogeny; time of the most recent common ancestor |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms azrahani halim |
| Date Deposited: | 29 Jan 2013 03:21 |
| Last Modified: | 11 Nov 2019 06:39 |
| URI: | http://eprints.um.edu.my/id/eprint/4589 |
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