Maulina, Tantry and Purnomo, Yohanes Yoppy and Khamila, Nadya and Garna, Devy and Sjamsudin, Endang and Cahyanto, Arief (2024) Analgesic Potential Comparison Between Piperine-Combined Curcumin Patch and Non-Piperine Curcumin Patch: A Pragmatic Trial on Post-Cleft Lip/Palate Surgery Pediatric Patients. Journal of Pain Research, 17. pp. 1903-1915. ISSN 1178-7090, DOI https://doi.org/10.2147/JPR.S463159.
Full text not available from this repository.Abstract
Purpose: Despite its well-acknowledged analgesic potential, curcumin's low bioavailability has been recognized. Piperine, a substance naturally contained in pepper, has been known for its effect on increasing curcumin bioavailability. To investigate the analgesic potential of curcumin and piperine addition to curcumin patch used as adjuvant therapy in the management of acute postoperative orofacial pain. Patients and Methods: This pragmatic trial recruited 75 patients that underwent oromaxillofacial surgery at Unpad Dental Hospital, Bandung, Indonesia. Research participants were randomly assigned to three different groups: the first group that did not receive any intervention other than the post-operative standard treatment (POST), the second group that received POST and non-piperine curcumin patch, and the third group that received POST and piperine-combined curcumin patch. Participants' pain intensity was evaluated by using the face, leg, activity, cry, and consolability (FLACC) pain scale and salivary prostaglandin-E2 (PGE2) level for two-time points, which were eight hours apart. All data were gathered and analyzed to compare the within and between-group differences. Results: Within groups comparison of the FLACC scores for two evaluation points showed significant differences for all groups (p < 0.01). For salivary PGE2 analysis, a comparison of the non-piperine group to the piperine group also showed significant results. Yet, when all three groups were compared, regardless of the differences, the results were not statistically significant. Conclusion: Despite of the proven efficacy of curcumin patch, the addition of piperine to the curcumin patch in the current study did not provide any significant effects. Further investigation is of importance.
| Item Type: | Article |
|---|---|
| Funders: | University of Padjadjaran, Bandung, Indonesia |
| Uncontrolled Keywords: | curcumin; piperine; acute postoperative pain; oromaxillofacial surgery; cleft lip; cleft palate |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Department of Restorative Dentistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Nov 2024 08:44 |
| Last Modified: | 13 Nov 2024 08:44 |
| URI: | http://eprints.um.edu.my/id/eprint/45881 |
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